Literature Discussion VI

Read Lu et al. (2002) Science 298: 2378.

Also, refer to chapter 14 and Gilbert website 14.3 for more information on muscle development and the myogenic bHLH genes.

 

Your answers to the discussion questions should be in complete sentences.

 

1.  The authors suggest that MyoR and capsulin have redundant functions.  Propose a molecular model to explain the functions of each of these two transcription factors in facial muscle development in normal and in mutant mice. 

a.     Model for functions of MyoR and capsulin in wild type mice

b.     Explain how your model predicts the phenotype of MyoR -/- mice

c.     Explain how your model predicts the phenotype of capsulin -/- mice

d.     Explain how your model predicts the phenotype of MyoR-/-; capsulin -/- mice

 

2.  Certain head-specific muscles are lacking in the double mutant mice.  Describe a model to explain the fate of these facial muscle precursor cells in MyoR-/-; capsulin -/- mice.  Did the authors provide any data to support or refute this model?