Yaping Feng

 L. H. Baker center for bioinformatics and biological statistics, Iowa State University

Phone: 515-294-5445
Email: ypfeng@iastate.edu

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Education

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Ph.D, in Biochemistry, bioinformatics and biological statistics fields, Iowa State University, May 2008.  Advisor: Robert Jernigan,

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M.S. in Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, July 2001

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B.S. in Biology,  NanKai University, Tianjin, China, June 1998

 

Skills

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Experience in bioinformatics tools: PDB, BLAST, VMD, CHARMM, CABS etc.

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Experience in statistical software: SAS, R and Sigmaplot

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Experience in database query language: SQL, JDBC, XML

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Experience in programming using C++, perl and Matlab

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Familiarity with Linux/Unix, Microsoft windows

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Familiarity with wet lab technologies in molecular biology, biochemistry and pharmacology

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Fluency in both Chinese and English

 Research Experience

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Research Assistant in the department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, 2002-Present
-- Development of new statistical potentials for protein structure prediction
--Studied residue packing of proteins using probability and statistics methods
--Combination of elastic network model and MC algorithm for studying protein conformational change

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Research Assistant in Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 1998-2001
-- Studied the structure and function of opioid receptors and the binding of analgesia (pain relieve) drugs
-- Experience in these biological technologies: molecular cloning, cell culture and protein expression, protein separation and purification, drug and receptor binding

Work Experience

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Employee in the department of research and development, Jianfeng Pharmaceutical Company, China, 2001-2002
--Coordinator of clinical trial

Publications (other 3 in preparation)

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Feng YP, Kloczkowski K, Jernigan RL. Orientational distributions of contact clusters in proteins closely resemble those of an icosahedron.(Accepted, Proteins: Structure, Function, and Bioinformatics)

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Feng YP, Kloczkowski K, Jernigan RL. Four-body contact potentials derived from two protein datasets to discriminate native structures from decoys. Proteins: Structure, Function, and Bioinformatics 68: 57 – 66, 2007

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Taner, S.T., Feng, Y, Garcia, J.V., Kloczkowski, A., Jernigan, R.L. The extent of cooperativity of protein motions observed with elastic network models is similar for atomic and coarser-grained models. Journal of Chemical theory and computation. J. Chem. Theory Comput., 2 (3), 696 -704, 2006.

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Feng YP, Chen LW, Zhou DH, Chen J, Xu XJ, Chi ZQ. Analysis of binding domain and function of chimeric mu/kappa opioid receptors to ohmefentanyl stereoisomers. Acta Pharmacol Sin. Nov;22(11):981-5, 2001

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Chen LW, Feng YP, Zhou DH , Xu XJ, Chen J, Wei Q, and Chi ZQ. One-Step Affinity Purification of Human Mu-Opioid Receptor Overexpressed in Baculovirus System. Protein and Peptide Letters, 8(4):265-272, 2001

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Wan XH, Huang XQ, Zhou DH, Jiang HL, Feng YP, Chen KX, and Chi ZQ Molecular Modeling of Kappa Opioid Receptor-Gi Protein Recognition. Protein and Peptide Letters, 7(6):403-409, 2000

Presentation

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New statistical potentials for improved threading. The Biophysical Society 51st Annual Meeting, March 2007, Baltimore, Maryland

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Four-body contact potentials derived from two datasets to determine native structures from decoys. The 5th Annual Joint Bioinformatics Workshop between UI and ISU, July 2005, Iowa City, IA, USA.

 Teaching Experience

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Teaching Assistant, Survey of Biochemistry (BBMB301), Fall 2005

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Teaching Assistant, Biochemistry (BBMB405), Spring 2005
 

Main Honors 

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Research Excellence Award, Iowa State University, 2007

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Premium for Academic Excellence (PACE) Award, Iowa State University, 2002

 

References

Dr. Robert L. Jernigan
Director of L. H. Baker center for bioinformatics and biological statistics
Professor of department of biochemistry, biophysics and molecular biology
112 Office and Lab Building
Iowa State University
Ames, IA 50011
Phone: 515-294-3833
Email: Jernigan@iastate.edu
Fax: 515-294-3841

Dr. Andrzej Kloczkowski
Senior scientist of plant sciences institute
Adjunct professor of department of biochemistry, biophysics and molecular biology
108 Office and Lab building

Iowa State University

Ames, IA 50011

Phone: 515-294-7261

Email: kloczkow@iastate.edu
Fax:515-294-3841

 Dr. Zhijun Wu
Associate professor of  department of mathematics
Program on bioinformatics and computational biology
307 Carver Hall
Iowa State University
Ames, IA 50011
Phone: 515-294-8165
Email: zhijun@iastate.edu
Fax: 515-294-5454