Zinc Finger ConsortiumThe Voytas Lab is a founding member of the Zinc Finger Consortium, promoting research and development of engineered zinc finger technologies.
|
 
Roy J. Carver Co-Laboratory
Welcome to the Voytas Lab!
We are in the Department of Genetics, Development & Cell Biology at Iowa State University. Our laboratory is located on the first floor of the Roy J. Carver Co-Laboratory--the home for Iowa State's Plant Sciences Institute. Please follow the links on the left for information on laboratory research, people and publications. For information on graduate programs, please visit the websites of the interdepartmental programs in Genetics, Microbiology, Molecular, Cellular & Developmental Biology, or Bioinformatics and Computational Biology.
Dan Voytas |
News & Updates
Molecular Cell paper reveals host regulation of Ty5 target specificity.In a recent issue of Molecular Cell (27:289-299), the Voytas lab demonstrates that Ty5 integrase is phosphorylated and that phosphorylation is required for targeting to heterochromatin. In the absence of phosphorylation, Ty5 integrates randomly throughout the genome and frequently causes mutations. Under stress conditions, phosphorylation is decreased, indicating that the host regulates target specificity through post-translational modification of integrase. This supports McClintock's hypothesis that mobile elements restructure host genomes as an adaptive response to environmental challenge.
Zinc Finger Consortium article published in Nature ProtocolsThe Zinc Finger Consortium has published its first paper entitled "Standardized Reagents and Protocols for Engineering Zinc Finger Nucleases by Modular Assembly" in the journal Nature Protocols (1:1637-1652). This paper describes reagents for creating zinc finger domains by modular assembly that are compatible with the unified Zinc Finger Consortium
|
Voytas Lab, 1035A Roy J. Carver Co-Labs, (515) 294-1963
Copyright © 2006, Iowa State University of Science and Technology. All rights reserved.