Laboratory of Evolutionary and Ecological Genomics

Dr. Nicole Valenzuela

Department of Ecology, Evolution, and Organismal Biology
Iowa State University
239 Bessey Hall
Ames, IA 50011
(515) 294-1285
nvalenzu@iastate.edu

People

 


 

 


 

Dr. Nicole Valenzuela

I am an evolutionary biologist, and my research involves studies of:
  • Evolutionary and Ecological Genomics
  • Evolutionary Developmental Biology
  • Sex Determination
  • Population and Ecological Genetics
  • Life History Evolution
  • Herpetology
  • Tropical Biology
  • Conservation
Publications

 

 

 


Robert Literman

    I am a third year PhD student in the Ecology and Evolutionary Biology program. I am interested in the evolution and functional basis of sex determination in reptiles. I am also a herp enthusiast, and have worked with reptiles in Costa Rica and New Zealand.
Bob’s Website

Srihari Radhakrishnan

I am a second year Ph.D. student in the Bioinformatics & Computational Biology program. I am interested in the transcriptomic analysis of gonadal development in turtles.

 


Emily Barks

I am a first year Master's student in the Interdepartmental Genetics program. I am interested in evolutionary developmental biology of sex determination in turtles, particularly the involvement of epigenetics processes.

 


Dr. Daleen Badenhorst

I am a postdoctoral fellow. My previous work focused on the Rattus complex and its role as a reservoir for human pathogens using a molecular cytogenetic, phylogenomic and gene expression approach. I am now working on a phylogenomics project to study the evolution of sex chromosomes and sex-linked genes in turtles.

My work is funded by the National Science Foundation (MCB 0815354 to N. Valenzuela and S.V. Edwards).

Daleen's Website

 


Dr. Daniel Janes

I am a postdoctoral fellow. I am an evolutionary geneticist interested in the evolution of sex-determining mechanisms and sex chromosomes.

My work is funded by the National Science Foundation (MCB 0815354 to N. Valenzuela and S.V. Edwards).

Dan's Website

Janes, D.E., Valenzuela N., Ezaz T., Amemiya C., and Edwards S.V. 2011. Sex chromosome evolution in Amniotes: applications for bacterial artificial chromosome libraries. Journal of Biomedicine and Biotechnology Vol 2011, doi:10.1155/2011/132975

 


Former Lab Members

Dr. Claudia Ceballos

I completed my Ph.D. in the EEB program at ISU in 2010. I am interested in understanding the causes and consequences of phenotypic evolution. My PhD work focused on phenotypic plasticity of body growth and its effect on the evolution of sexual size dimorphism in Podocnemis expansa and Chelydra serpentina and the evolution of Rensch's rule in turtles. My work was funded by the National Science Foundation (DEB 0808047) and the Turtle Conservation Fund, to N. Valenzuela (PI) and C Ceballos (CoPI).

I am now a Lecturer Faculty at the Veterinary Medicine Program of the University of Antioquia, Colombia.

Claudia’s Website

Ceballos, C. and Valenzuela, N. 2011. The role of sex-specific plasticity in shaping sexual dimorphism in a long-lived vertebrate, the snapping turtle Chelydra serpentina. Evolutionary Biology 38: 163-181.


Dr. Jennifer Neuwald

I am a postdoctoral fellow. My previous work focused on the temporal changes in population genetic dynamics of the eastern collared lizard, Crotaphytus collaris collaris, in response to forest fire management. I am now working on an eco-genomics project to study the effect of fluctuating temperature on the expression of genes involved in gonadogenesis in TSD turtles.

My work is funded by the National Science Foundation (IOS 0743284 to N. Valenzuela).

Jennifer's Website

Neuwald J.L. and Valenzuela N. 2011. The Lesser Known Challenge of Climate Change: Thermal Variance and Sex-Reversal in Vertebrates with Temperature-Dependent Sex Determination. PloS ONE 6(3): e18117. doi:10.1371/journal.pone.0018117

 


 

Dr. Jennifer Deitloff

I completed my Ph.D. in the EEB program at ISU in 2008. My work focused on the ecological processes responsible for species co-ocurrence patterns in two species of Plethodon salamanders. I was co-advised by Dr. Dean Adams.

I am now a Postdoctoral Scholar in the Department of Biological Sciences at Auburn University.

Jennifer's Website


 

Dr. Tibisay Escalona

I was an NSF postdoctoral fellow. I am very interested in the ecology, life history evolution and conservation of freshwater turtles in the Neotropics. I worked on the metapopulation genetic analysis of Podocnemis unifilis turtles in South America.

My work was funded by the National Science Foundation (DBI 0511958 to T. Excalona), and the Scott Neotropical Fund from the Cleveland Zoo (to N. Valenzuela [PI] and T. Escalona [CoPI]).

I am currently a fellow at the laboratory of Ecotoxicology, Genomics and Evolution at CIMAR in Portugal.

Tibisay’s Website

Escalona, T., Engstrom T.N., Hernandez O.E., Bock B.C., Vogt R.C. and Valenzuela N. 2009. Population genetics of the endangered South American freshwater turtle, Podocnemis unifilis, inferred from microsatellite DNA data. Conservation Genetics. DOI 10.1007/s10592-008-9746-3

Escalona, T., Adams, D.C., and Valenzuela, N. 2009. Nesting ecology in the freshwater turtle Podocnemis unifilis: spatiotemporal patterns and inferred explanations. Functional Ecology DOI 10.1111/j.1365-2435.2009.01562.x

 


Dr. Takahito Shikano

Postdoctoral associate. I worked on the molecular evolution of sex related genes across reptiles and other vertebrates that possess contrasting sex determining mechanisms, in order to shed light on the evolution of sex determination.

I am now a Postdoc in the Ecological Genetics Research Unit at the University of Helsinki.

Taka's Website

  • Valenzuela, N., LeClere A.R, and Shikano T. 2006. Comparative expression of steroidogenic factor 1 in Chrysemys picta and Apalone mutica turtles with environmental and genotypic sex determination. Evolution and Development 8 (5): 424-432.

  • Valenzuela, N. and Shikano T. 2007. Embryological ontogeny of Aromatase gene expression in Chrysemys picta and Apalone mutica turtles: comparative patterns within and across temperature-dependent and genotypic sex-determining mechanisms. Development, Genes and Evolution 217: 55-62.

 


Pedro Martinez

I was a Ph.D. student in the Ecology and Evolutionary Biology Program (2006-2008) and the Genetics Program (2008-2009) at ISU. I worked on sex chromosome evolution in turtles, particularly in discovering a novel XX/XY system in the Australian chelid Emydura macquarii. I am now a graduate student in Veterinary Medicine at ISU.

 

Martinez, P., Ezaz T., Valenzuela, N., Georges, A., and Graves J.A.M. 2008. An XX/XY heteromorphic sex chromosome system in the Australian chelid turtle Emydura macquarii, a new piece in the puzzle of sex chromosome evolution in turtles. Chromosome Research: 16(6): 815-825. DOI 10.1007/s10577-008-1228-4.

 


Andrea R. LeClere

I graduated from the undergraduate Genetics program at ISU. For my honors thesis I worked during 2004-2005 on a project aimed to compare the expression profiles of sex genes (genes involved in sex differentiation) between turtles with temperature-dependent sex determination (Chrysemys picta) and turtles with genotypic sex determination (Apalone mutica) incubated under identical conditions. We were searching for key differences to understand the mechanics of both sex determining systems.

I am now a PhD student in the Molecular, Cellular and Structural Biology program at the University of Minnesota.

  • Valenzuela, N., LeClere A.R, and Shikano T. 2006. Comparative expression of steroidogenic factor 1 in Chrysemys picta and Apalone mutica turtles with environmental and genotypic sex determination. Evol. Dev. 8 (5): 424-432.

  • LeClere A.R. and N. Valenzuela.2005. Comparative gene expression of multiple sex-determining genes in TSD and GSD turtles. Joint Meeting of the Society for the Study of Amphibians and Reptiles and the Herpetologists' League, Tampa, Florida.

 


Barbara Kagima

I was a Biology undergraduate at ISU, and during 2002-2005 I worked on population genetics of Podocnemis unifilis turtles from Colombia and Peru, and on maternal-effect genes related to sex differentiation in Chrysemys picta turtles from North America. I completed my Master’s in 2008 in the EEB program at ISU working on Wildlife Management with Dr. Sue Fairbanks. I am now a PhD student at the University of Nebraska Lincoln.

  • Kagima, B. and N. Valenzuela. 2005. Maternal effect genes for sex determination in painted turtles, Chrysemys picta. Joint Meeting of the Society for the Study of Amphibians and Reptiles and the Herpetologists' League, Tampa, Florida.

  • Kagima, B., Valenzuela, N., Engstrom, T., and Bock, B. 2004. Preliminary population genetic study of the yellow spotted Amazon river turtle (Podocnemis unifilis) using microsatellite DNA data. Annual Meeting of the Society of Integrative and Comparative Biology, New Orleans, Louisiana.

 


Sonia Morrone and Anthony Siegle

We were ITA interns at the Valenzuela Lab during 2008-2009, and were Biology majors at ISU. We worked on developmental biology and the effect of incubation temperature and posthatching environment on growth of snapping turtles, Chelydra serpentina.

  • Morrone S. and Siegle A. 2009. Effects of environment on growth. Iowa Academy of Sciences Annual Meeting,Des Moines, IA.

 


Katherine L. O'Shaughnessy

I was a summer intern with the ITA program at the Valenzuela Lab and the REU in Molecular Biotechnology and Genomics at ISU in 2009. I worked on developmental biology and expression profiling of genes involved in sex determination in turtles. I am now a Ph.D. student at the University of Florida where I am studying vetebrate EvoDevo.

  • O’Shaughnessy K, Valenzuela, N, Neuwald, N, Literman, R, Manternach, T, Harris, A. 2010. The genomics of temperature dependent sex determination in Chrysemys picta. Experimental Biology FASEB Annual Meeting, Anaheim, CA. Poster & Invited oral presentation - Winner of NSF travel grant for undergraduates - Winner of "ASBMB's Best Poster Theme" in the category of Systems Biology, Synthetic Biology, and Signal Transduction.

  • O'Shaughnessy K, Valenzuela, N, Neuwald, J, Literman, R, Manternach, T, Harris, A. 2010. The Genetic mechanism of temperature-dependent sex determination in the painted turtle. Capital University Research Symposium, Columbus, OH. Winner of Capital University's endowed "Bruning Award" for excellence in research.

 


Kevin Wenceslao

I was an ITA intern at the Valenzuela Lab during 2010-2011. I am a Biology major at ISU. I worked on developmental biology and the effect of incubation temperature on growth of painted turtles posthatching.

  • Wenceslao K, Literman R, Neuwald J, and Valenzuela N. 2011. The effect of temperautre on sex determination and fitness in painted turtles. Iowa Academy of Sciences Annual Meeting, Waverly, IA.

 


Chris Chandler

I was a Ph.D. rotation student in the Ecology and Evolutionary Biology program. I am interested in the evolution of sex determination.

 

 


Jeffrey Sander

I was a Ph.D. rotation student from the Bioinformatics & Computational Biology program. I worked on sex ratio evolution models.

 

Jacqueline Farrel


I was a MSc rotation student from the Interdepartmental Genetics program. I worked on the molecular evolution of genes involved in sex determination.

 

William Pett


I was a Ph.D. rotation student from the Bioinformatics & Computational Biology program. I worked on the transcriptomic analysis of gonadal development in turtles.