Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology

Nikolau Group Publications

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Refereed Publications

Bender RL, Fekete ML, Klinkenberg PM, Hampton MW, Bauer B, Malecha M, Lindgren K, Maki J, Perera MA, Nikolau BJ, Carter CJ. 2013. PIN6 is required for nectary auxin response and short stamen development. Plant J. 74(6):893-904. doi: 10.1111/tpj.12184. Epub 2013 May 2. PMID: 23551385.

Hur M, Campbell AA, Almeida-de-Macedo M, Li L, Ransom N, Jose A, Crispin M, Nikolau BJ, Wurtele ES. 2013. A global approach to analysis and interpretation of metabolic data for plant natural product discovery. Nat Prod Rep. 30(4):565-83. doi: 10.1039/c3np20111b. PMID: 23447050.

Jin H, Nikolau BJ. 2012. The role of genetic redundancy in polyhydroxyalkanoate (PHA) polymerases in PHA biosynthesis in Rhodospirillum rubrum. J. Bacteriology. 194(20):5522-9. Epub 2012 Aug 3. PMID: 22865850.

Muhlemann J, Maeda H, Chang CY, San Miguel P, Baxter I, Cooper B, Perera MA, Nikolau BJ, Vitek O, Morgan JA, Dudareva N. 2012. Developmental changes in the metabolic network of snapdragon flowers. PLoS ONE 7(7):e40381. doi: 10.1371/journal.pone.0040381. Epub 2012 Jul 11. PMID: 22808147.

Quanbeck, SM, Brachova L, Campbell AA, Guan X, Perera  A, He K, Rhee SY, Bais P, Dickerson JA, Dixon P, Wohlgemuth G, Fiehn O, Barkan L, Lange I, Lange BM, Lee I, Cortes D, Salazar C, Shuman J, Shulaev V, HuhmanDV, Sumner LW, Roth MR, Welti R, Ilarslan H, Wurtele ES and Nikolau BJ. 2012. Metabolomics as a hypothesis-generating functional genomics tool for the annotation of Arabidopsis thaliana genes of "unknown function." Frontiers in Plant Science 3:15. doi: 10.3389/fpls.2012.00015. eCollection 2012. PMID: 22645570.

Lee Y J; Perdian D C; Song Z H; Yeung E S; Nikolau B J . 2012. Use of mass spectrometry for imaging metabolites in plants. Plant Journal 70(1):81-95. doi: 10.1111/j.1365-313X.2012.04899.x. PMID: 22449044.

Wurtele, ES, Cappell, J, Jones, AD, Celiz, MD, Ransom, N, Hur, M, Rizshsky, L, Crispin, M, Dixon, P, Liu, J, Widrlechner, MP, and Nikolau, BJ. 2012. Medicinal plants: A public resource for metabolomics and hypothesis development. Metabolites 2(4): 1031-1059. doi:10.3390/metabo2041031.

Jin H, Song Z, Nikolau BJ. 2012. Reverse genetic characterization of two paralogous acetoacetyl CoA thiolase genes in Arabidopsis reveals their importance in plant growth and development. Plant J. 70(6):1015-32. doi: 10.1111/j.1365-313X.2012.04942.x. Epub 2012 Mar 31. PMID: 22332816.

Huang N, Rizshsky L, Hauck CC, Nikolau BJ, Murphy, PA. 2012. The inhibition of lipopolysaccharide-induced macrophage inflammation by 4 compounds in Hypericum perforatum extract is partially dependent on the activation of SOCS3. Phytochemistry 76:106-16. doi: 10.1016/j.phytochem.2011.12.001. Epub 2012 Jan 13. PMID: 22245632.

Ding G, Che P, Ilarslan H, Syrkin Wurtle E, Nikolau BJ. 2011. Genetic dissection of methylcrotonyl-CoA carboxylase indicates a complex role for mitochondrial leucine catabolism during seed development and germination. Plant Journal 70(4):562-77. doi: 10.1111/j.1365-313X.2011.04893.x. Epub 2012 Feb 6. PMID: 22211474.

Zhang X, Rizshsky L, Hauck C, Qu L, Widrlechner MP, Nikolau BJ, Murphy PA, Birt DF. 2012. Bauer ketones 23 and 24 from Echinacea paradoxa var. paradoxa inhibit lipopolysaccharide-induced nitric oxide, prostaglandin E2 and cytokines in RAW264.7 mouse macrophages. Phytochemistry 74:146-58. doi: 10.1016/j.phytochem.2011.10.013. Epub 2011 Nov 29. PMID: 22133644.

Korte A R, Song ZH, Nikolau BJ, Lee YJ. 2012. Mass spectrometric imaging as a high-spatial resolution tool for functional genomics: Tissue-specific gene expression of TT7 inferred from heterogeneous distribution of metabolites in Arabidopsis flowers. Analytical Methods 4:474-481. doi: 10.1039/C2AY05618F.

Bais P, Moon-Quanbeck S, Nikolau BJ, Dickerson JA. 2011. Plant metabolomics.org: mass spectrometry-based Arabidopsis metabolomics - database and tools update. Nucleic Acids Research 40(Database issue):D1216-20. doi: 10.1093/nar/gkr969. Epub 2011 Nov 10. PMID: 22080512.

Huang N, Rizshsky L, Hauck C, Nikolau BJ, Murphy PA, Birt DF. 2011. Identification of anti-inflammatory constituents in Hypericum perforatum and Hypericum gentianoides extracts using RAW 264.7 mouse macrophages. Phytochemistry 72(16):2015-23. doi: 10.1016/j.phytochem.2011.07.016. Epub 2011 Aug 17. PMID:21855951.

Jing F, Cantu DC, Tvaruzkova J, Chipman JP, Nikolau BJ, Yandeau-Nelson MD, Reilly PJ. 2011. Phylogenetic and experimental characterization of an acyl ACP thioesterase family reveals significant diversity in enzymatic specificity and activity. BMC Biochem 12:44. doi: 10.1186/1471-2091-12-44. PMID: 21831316.

Chen Y, Apolinario E, Brachova L, Kelman Z, Li Z, Nikolau BJ, Showman L, Sowers K, Orban J. 2011. A nuclear magnetic resonance based approach to accurate functional annotation of putative enzymes in the methanogen Methanosarcina acetivorans. BMC Genomics 12 Suppl 1:S7. doi: 10.1186/1471-2164-12-S1-S7. PMID: 21810209.

Schmidt MA, Barbazuk B, Sandford M, May G, Song Z, Zhou W, Nikolau BJ, Herman EM. 2011. Silencing of soybean seed storage proteins results in a rebalanced protein composition preserving seed protein content without major collateral changes in the metabolome and transcriptome. Plant Physiology 156(1):330-45. doi: 10.1104/pp.111.173807. Epub 2011 Mar 10. PMID: 21398260.

Wu LK, Rowe EW, Jeftinija K, Jeftinija S, Rizshsky L, Nikolau BJ, McKay J, Kohut M, Wurtele ES. 2010. Echinacea-induced cytosolic Ca2+ elevation in HEK293. BMC Complement Altern Med 110:72. doi: 10.1186/1472-6882-10-72. PMID: 21092239.

Perera MADN, Qin W, Yandau-Nelson M, Fan L, Dixon P, Nikolau BJ. 2010. Biological origins of normal-chain hydrocarbons. Plant Journal 64(4):618-32. doi: 10.1111/j.1365-313X.2010.04355.x. Epub 2010 Oct 26. PMID: 21070415.

Li X, Ilarslan H, Brachova L, Qian HR, Li L, Che P, Wurtele ES, Nikolau BJ.  2011. Reverse genetic analysis of the two biotin-containing subunit genes of the heteromeric acetyl-CoA carboxylase indicates a unidirectional functional redundancy. Plant Physiology 155:293-314. doi: 10.1104/pp.110.165910. Epub 2010 Oct 28. PMID: 21030508.

Jiang Y, Nikolau BJ, Ma Y. 2010. Separation and quantification of short-chain coenzyme A in plant tissues by capillary electrophoresis with laser-induced fluorescence detection. Analytical Methods 2:1900-1904. doi: 10.1039/C0AY00425A.

Lalone CA, Huang N, Rizshsky L, Yum MY, Singh N, Hauck C, Nikolau BJ, Wurtele ES, Kohut ML, Murphy PA, Birt DF.  2010.  Enrichment of Echinacea angustifolia with Bauer alkylamide 11 and Bauer ketone 23 increased anti-inflammatory potential through interference with cox-2 enzyme activity. J Agric Food Chem 58(15):8573-84. doi: 10.1021/jf1014268. PMID: 20681645.

Jun JH, Song Z, Liu Z, Nikolau BJ, Yeung ES, Lee YJ.  2010. High-spatial and high-mass resolution imaging of surface metabolites of Arabidopsis thaliana by laser desorption-ionization mass spectrometry using colloidal silver. Analytical Chemistry 82(8):3255-65. doi: 10.1021/ac902990p. PMID: 20235569.

Bais P, Moon SM, He K, Leitao R, Dreher K, Walk T, Sucaet Y, Barkan L, Wohlgemuth G, Roth MR, Wurtele ES, Dixon P, Fiehn O, Lange BM, Shulaev V, Sumner LW, Welti R, Nikolau BJ, Rhee SY, Dickerson JA.  2010.  PlantMetabolomics.org: a web portal for plant metabolomics experiments. Plant Physiology 152(4):1807-16. doi: 10.1104/pp.109.151027. Epub 2010 Feb 10. PMID: 20147492.

Huang N, Hauck C, Yum MY, Rizshsky L, Widrlechner MP, McCoy JA, Murphy PA, Dixon PM, Nikolau BJ, Birt DF.  2009. Rosmarinic acid in Prunella vulgaris ethanol extract inhibits lipopolysaccharide-induced prostaglandin E2 and nitric oxide in RAW 264.7 mouse macrophages. Journal of Agricultural Food Chemistry 57(22):10579-89. doi: 10.1021/jf9023728. PMID: 19919113.

LaLone CA, Rizshsky L, Hammer KD, Wu L, Solco AK, Yum M, Nikolau BJ, Wurtele ES, Murphy PA, Kim M and Birt DF.  2009. Endogenous levels of Echinacea alkylamides and ketones are important contributors to the inhibition of prostaglandin E2 and nitric oxide production in cultured macrophages. Journal of Agricultural Food Chemistry 57(19):8820-30. doi: 10.1021/jf901202y. PMID: 19807154.

Maury W, Price JP, Brindley MA, Oh C, Neighbors JD, Wiemer DF, Wills N, Carpenter S, Hauck C, Murphy P, Widrlechner MP, Delate K, Kumar G, Kraus GA, Rizshsky L and Nikolau BJ. 2009. Identification of light-independent inhibition of human immunodeficiency virus-1 infection through bioguided fractionation of Hypericum perforatum. Virology Journal 6:101. doi: 10.1186/1743-422X-6-101. PMID: 19594941.

Oliver DJ, Nikolau BJ, Wurtele ES.  2009. Acetyl-CoA—Life at the metabolic nexus. Plant Science 176: 597-601. http://dx.doi.org/10.1016/j.plantsci.2009.02.005

Cha S, Song Z, Nikolau BJ and Yeung ES. 2009. Direct profiling and imaging of epicuticular waxes on Arabidopsis thaliana by laser desorption/ionization mass spectrometry using silver colloid as a matrix. Analytical Chemistry 81(8):2991-3000. doi: 10.1021/ac802615r. PMID: 19290666.

Perera MA, Choi SY, Wurtele ES and Nikolau BJ. 2009. Quantitative analysis of short-chain acyl-coenzymeAs in plant tissues by LC-MS-MS electrospray ionization method. J Chromatography B Analytical Technology Biomedical Life Science 877(5-6):482-8. doi: 10.1016/j.jchromb.2008.12.053. Epub 2008 Dec 30. PMID: 19157998.

Brindley MA, Widrlechner MP, McCoy JA, Murphy P, Hauck C, Rizshsky L, Nikolau BJ and Maury W. 2009.  Inhibition of lentivirus replication by aqueous extracts of Prunella vulgaris. Virology Journal 6:8. doi: 10.1186/1743-422X-6-8. PMID: 19154592.

Wu L, Dixon PM, Nikolau BJ, Kraus GA, Widrlechner MP, Wurtele ES. 2009. Metabolic Profiling of Echinacea Genotypes and a Test of Alternative Taxonomic Treatments. Planta Medica 75(2):178-83. doi: 10.1055/s-0028-1112199. Epub 2008 Dec 19. PMID: 19101884.

Mentzen WI, Peng J, Ransom N, Nikolau BJ, Wurtele ES. 2008. Articulation of three core metabolic processes in Arabidopsis: fatty acid biosynthesis, leucine catabolism and starch metabolism. BMC Plant Biology 8:76. doi: 10.1186/1471-2229-8-76. PMID: 18616834.

Nikolau BJ, Perera MA, Brachova L, Shanks B. 2008. Platform biochemicals for a biorenewable chemical industry. Plant Journal 54(4):536-45. doi: 10.1111/j.1365-313X.2008.03484.x. PMID: 18476861.

Aguilar JA, Diaz-Perez C, Diaz-Perez AL, Rodriguez-Zavala JS, Nikolau BJ, Campos-Garcia J. 2008. Substrate specificity of the 3-methylcrotonyl coenzyme A (CoA) and geranyl-CoA carboxylases from Pseudomonas aeruginosa. Journal Bacteriology 190(14):4888-93. doi: 10.1128/JB.00454-08. Epub 2008 May 9. PMID: 18469096.

Cha S, Zhang H, Ilarslan HI, Wurtele ES, Brachova L, Nikolau, BJ, Yeung, ES. 2008. Direct profiling and imaging of plant metabolites in intact tissues by using colloidal graphite-assisted laser desorption ionization mass spectrometry. Plant Journal 55(2):348-60. doi: 10.1111/j.1365-313X.2008.03507.x. Epub 2008 Apr 4. PMID: 18397372.

Fiehn O, Wohlgemuth G, Scholz M, Kind T, Lee do Y, Lu, Y., Moon, S., Nikolau, BJ. 2008. Quality control for plant metabolomics: reporting MSI-compliant studies. Plant Journal 53(4):691-704. doi: 10.1111/j.1365-313X.2007.03387.x. PMID: 18269577.

Muralla R, Chen E, Sweeney C, Gray JA, Dickerman A, Nikolau, B.J., Meinke, D. 2008. A bifunctional locus (BIO3-BIO1) required for biotin biosynthesis in Arabidopsis. Plant Physiology 146(1):60-73. Epub 2007 Nov 9. PMID: 17993549.

Yandeau-Nelson MD, Nikolau BJ, Schnable PS.  2006. Effects of trans-acting Genetic Modifiers on Meiotic Recombination Across the a1-sh2 Interval of Maize. Genetics 174(1):101-12. Epub 2006 Jul 2. PMID: 16816431.

Dietrich CR, Perera MADN, Yandeau M, Meeley RB, Nikolau BJ, Schnable PS. 2005. Characterization of two gl8 paralogs reveals that the 3-ketoacyl reductase component of fatty acid elongase is essential for maize (Zea mays L.) development. Plant Journal 42(6):844-61. PMID: 15941398.

Sluszny C, Yeung ES, Nikolau BJ. 2005 In situ probing of the biotic-abiotic boundary of plants by laser desorption/ionization time-of-flight mass spectrometry. Journal of the American Society of Mass Spectrometry. 16(1):107-15. PMID: 15653370.

Fatland BL, Nikolau BJ, Wurtele ES. 2005. Reverse Genetic Characterization of Cytosolic Acetyl-CoA Generation by ATP-citrate lyase in Arabidopsis. Plant Cell 17(1):182-203. Epub 2004 Dec 17. PMID: 15608338.

Yandeau-Nelson MD, Zhou Q, Yao H, Xu X, Nikolau BJ, Schnable PS. 2005. MuDR transposase increases the frequency of meiotic crossovers in the vicinity of a Mu insertion in the maize a1 gene. Genetics 169(2):917-29. Epub 2004 Oct 16. Erratum in: Genetics. 2005 Oct;171(2):865. PMID: 15489518.

Che P, Weaver LM, Wurtele ES, Nikolau BJ. 2003. The role of biotin in regulating 3-methylcrotonyl-CoA carboxylase expression in Arabidopsis Plant Physiology 131(3):1479-86. PMID: 12644697.

Fatland BL, Ke J, Anderson M, Mentzen W, Cui LW, Allred C, Johnston JL, Nikolau BJ, Wurtele ES. 2002. Molecular characterization of a novel heteromeric ATP-citrate lyase that generates cytosolic pool of acetyl-CoA in Arabidopsis. Plant Physiology 130(2):740-56. PMID: 12376641.

Che P, Wurtele ES, Nikolau BJ. 2002. Metabolic and environmental regulation of 3-methylcrotonyl-coenzyme A carboxylase expression in Arabidopsis Plant Physiology 129(2):625-37. PMID: 12068107.

Yao H, Zhou Q, Li J, Smith H, Yandeau M, Nikolau BJ, Schnable PS. 2002. Molecular characterization of meiotic recombination across the 140-kb multigenic a1-sh2 interval of maize. Proceedings National Academy Science U.S.A. 99(9):6157-62. Epub 2002 Apr 16. PMID: 11959909.

Xu X, Dietrich CR, Lessire R, Nikolau BJ, Schnable PS. 2002. The endoplasmic reticulum-associated maize GL8 protein is one of the components of the acyl-CoA elongase complex involved in the production of cuticular waxes. Plant Physiology 128(3):924-34. PMID: 11891248.

Dietrich CR, Cui F, Packila M, Ashlock D, Nikolau BJ, Schnable PS. 2002. Maize Mu transposons are targeted to the 5' UTR of the gl8a gene and sequences f BJlanking Mu target site duplications throughout the genome exhibit non-random nucleotide composition. Genetics 160(2):697-716. PMID: 11861572.

Fatland B, Anderson M, Nikolau BJ, Wurtele ES. 2000. Molecular biology of cytosolic acetyl-CoA generation. Biochem Soc Trans 28(6):593-5. PMID: 11171137.

Nikolau BJ, Oliver DJ, Schnable PS, Wurtele ES. 2000. Molecular biology of acetyl-CoA metabolism. Biochem Soc Trans 28(6):591-3. PMID 11171136.

Ke J, Behal RH, Back SL, Nikolau BJ, Wurtele ES, Oliver DJ. 2000. The role of pyruvate dehydrogenase and acetyl-CoA synthetase in fatty acid synthesis in developing Arabidopsis seeds. Plant Physiology 123(2):497-508. PMID: 10859180.

Ke J, Wen TN, Wurtele ES, Nikolau BJ. 2000. Coordinate regulation of the spatial and temporal expression of the nuclear and chloroplastic encoded genes of the heteromeric acetyl-CoA carboxylase. Plant Physiology 122(4):1057-71. PMID: 10759501.

McKean AL, Ke J, Song J, Che P, Achenbach S, Nikolau BJ, Wurtele ES. 2000. Molecular characterization of the non-biotin-containing subunit of 3-methylcrotonyl-CoA carboxylase. Journal of Biological Chemistry 275(8):5582-90. PMID: 10681539.

Liu L, Hammond EG, Nikolau BJ. 1998. In vivo studies of the biosynthesis of vernolic acid in the seeds of Vernonia galamensis. Lipids 33(12):1217-21. PMID: 9930408.

Guan X, Diez T, Prasad KT, Nikolau BJ, Wurtele ES. 1999. Geranoyl-CoA carboxylase: A novel biotin-containing enzyme in plants. Archives of Biochemistry and Biophysics 362(1):12-21. PMID: 9917324.

Anderson MD, Che P, Song J, Nikolau BJ, Wurtele ES. 1998. 3-Methylcrotonyl-CoA carboxylase is a component of the mitochondrial leucine catabolic pathway in plants. Plant Physiology 118(4):1127-38. PMID: 9847087.

Caffrey JJ, Choi JK, Wurtele ES, Nikolau BJ. 1998. Tissue distribution of acetyl-CoA carboxylases in leaves of leek (Allium porrum L.). Journal of Plant Physiology 153:265-269. doi.org/10.1016/S0176-1617(98)80150-8.

Sun J, Ke J, Johnson JL, Nikolau BJ, Wurtele ES. 1997. Biochemical and molecular biological characterization of CAC2: The Arabidopsis thaliana gene coding for the biotin carboxylase subunit of the plastidic acetyl-CoA carboxylase. Plant Physiology 115(4):1371-83. PMID: 9414551

Xia Y, BJ Nikolau, and PS Schnable. 1997. Developmental and hormonal regulation of the Arabidopsis CER2 gene which codes for a nuclear localized protein required for the normal accumulation of cuticular waxes. Plant Physiology 115(3):925-37. PMID: 9390429.

Xu XJ, Xia YJ, Dietrich C, Nikolau BJ, Schnable PS. 1997. Sequence analysis of the cloned glossy8 gene of maize suggests that it may code for a b-ketoacyl reductase required for the biosynthesis of cuticular waxes. Plant Physiology 115(2):501-10. PMID: 9342868.

Liu L, Hammond EG, Nikolau BJ. 1997. In vivo studies of the biosynthesis of a-eleostearic acid in the seeds of Momordica charantia L. Plant Physiology 113(4):1343-1349. PMID: 12223677.

Hansen JD, Pyee J, Y. Xia Y, Wen T-J, Robertson DS, Kolattukudy PE, Nikolau BJ, Schnable PS. 1997. The glossy1 locus of Zea mays L. and an epidermis-specific cDNA from Kleinia odora define a class of receptor-like proteins required for the normal accumulation of cuticular waxes. Plant Physiology 113(4):1091-100. PMID: 9112770.

Ke J, Choi J-K, Smith M, Horner HT, Nikolau BJ, Wurtele ES. 1997. Structure of the CAC1 gene and in situ characterization of its expression: The Arabidopsis thaliana gene coding for the biotin-containing subunit of the plastidic acetyl-CoA carboxylase. Plant Physiology 113(2):357-65. PMID: 9046589.

Xia YJ, Nikolau BJ, Schnable PS. 1996. Cloning and characterization of CER2, an Arabidopsis gene that affects cuticular wax accumulation. Plant Cell 8(8):1291-304. PMID: 8776898.

Weaver LM, Yu F, Wurtele ES, Nikolau BJ. 1996. Characterization of the cDNA and gene coding for the biotin synthase of Arabidopsis thaliana. Plant Physiology 110(3):1021-8. PMID: 8819873.

Xu X, Hsia A-P, Zhang L, Nikolau BJ, Schnable PS. 1995. Meiotic recombination breakpoints resolve at high rates at the 5' end of a maize coding sequence. Plant Cell 7(12):2151-61. PMID: 8718625.

Chen L, Moon Y, Shanklin J, Nikolau BJ, Atherly AG. 1995. Cloning and sequence of a cDNA encoding stearoyl-acyl carrier protein desaturase from Glycine max. Plant Physiology 109: PGR95-105.

Choi J-K, Fei Y, Wurtele ES, Nikolau BJ. 1995. Molecular cloning and characterization of the cDNA coding for the biotin-containing subunit of the chloroplastic acetyl-CoA carboxylase. Plant Physiology 109(2):619-25. PMID: 7480350.

Wang X, Wurtele ES, Nikolau BJ. 1995. Regulation of b-methylcrotonyl-CoA carboxylase activity by biotinylation of the apoenzyme. Plant Physiology 108(3):1133-1139. PMID: 12228532.

Yanai Y, Kawasaki T, Shimada H, Wurtele ES, Nikolau BJ, Ichikawa N. 1995. Genomic organization of the 251 kDa acetyl-CoA carboxylase genes in Arabidopsis: Tandem gene duplication has made two differentially expressed isozymes. Plant and Cell Physiology 36(5):779-87. PMID: 7551584.

Weaver LM, Lebrun L, Wurtele ES, Nikolau BJ. 1995. Molecular cloning of the biotinylated subunit of 3-methylcrotonyl-coenzyme A carboxylase of Arabidopsis thaliana. Plant Physiology 107(3):1013-4. PMID: 7716229.

Schnable PS, Stinard PS, Wen TJ, Heinen S, Weber D, Zhang L, Hansen JD, Nikolau BJ. 1994. The genetics of cuticular wax biosynthesis. Maydica 39:279-287.

Civardi L, Xia Y, Edwards KJ, Schnable PS, Nikolau BJ. 1994. The relationship between the genetic and physical distances in the cloned a1-sh2 interval of the Zea mays L. genome. Proceedings of the National Academy of Sciences U.S.A. 91(17):8268-72. PMID: 8058793.

Song J, Wurtele ES, Nikolau BJ. 1994. Molecular cloning and characterization of the cDNA coding for the biotin-containing subunit of 3-Methylcrotonyl-CoA carboxylase: Identification of the biotin carboxylase and biotin-carrier domains. Proceedings of the National Academy of Sciences U.S.A. 91(13):5779-83. PMID: 8016064.

Wang X, Wurtele ES, Keller G, McKean AL, Nikolau BJ. 1994. Molecular cloning of cDNAs and genes coding for b-methylcrotonyl-CoA carboxylase of tomato. Journal of Biological Chemistry 269(16):11760-8. PMID: 8163472.

Diez TA, Wurtele ES, Nikolau BJ. 1994. Purification and Characterization of 3-Methylcrotonyl-Coenzyme A Carboxylase from Leaves of Zea mays. Archives of Biochemistry and Biophysics 310(1):64-7. PMID: 8161223.

Chen Y, Wang X, Nikolau BJ, Wurtele ES. 1993. Purification and characterization of 3-methylcrotonyl-CoA carboxylase from carrot. Archives of Biochemistry and Biophysics 305(1):103-9. PMID: 8393642.

Wurtele ES, Wang H, Durgerian S, Nikolau BJ, Ulrich TH. 1993. Characterization of a gene expressed early in somatic embryogenesis of Daucus carota. Plant Physiology 102(1):303-12. PMID: 8108498.

Wurtele ES, Nikolau BJ. 1992. Differential accumulation of biotin enzymes during carrot somatic embryogenesis. Plant Physiology 99(4):1699-703. PMID: 16669096.

Ulrich TH, Wurtele ES, Nikolau BJ. 1990. Sequence of an mRNA accumulating specifically in carrot somatic embryogenesis. Nucleic Acid Research 18(9):2826. PMID: 2339072.

Wurtele ES, Nikolau BJ. 1990. Plants contain multiple biotin enzymes: Discovery of 3-methylcrotonyl-CoA carboxylase, propionyl-CoA carboxylase and pyruvate carboxylase in the plant kingdom. Archives of Biochemistry and Biophysics 278(1):179-86. PMID: 2321957.

Wurtele ES, Keller GL, Nikolau BJ, Ulrich TH. 1988. Quantitation of starch and ADP-glucose pyrophosphorylase in non-embryogenic cells and embroygenic cell clusters from carrot suspension cultures. Journal of Plant Physiology 132:683-689.

Keller GL, Nikolau BJ, Ulrich TH, Wurtele ES. 1988. Comparison of starch and ADP-glucose pyrophosphorylase levels in non-embryogenic cells and developing embryos from induced carrot cultures. Plant Physiology 86(2):451-6. PMID: 16665929.

Nikolau BJ, Klessig DF. 1987. Coordinate, organ-specific and developmental regulation of ribulose-1,5-bisphosphate carboxylase gene expression in Amaranthus hypophondriacus. Plant Physiology 85(1):167-73. PMID: 16665651.

Carr JP, Dixon DC, Nikolau, Volkerding KV, Klessig DF. 1987. Synthesis and localization of pathogenesis-related proteins in tobaBJcco. Molecular and Cellular Biology 7(4):1580-3. PMID: 3299048.

Wurtele ES, Nikolau BJ. 1986. Enzymes of glucose oxidation in leaf tissues: The distribution of the enzymes of glycolysis and the oxidative pentose phosphate pathway between epidermal and mesophyll tissues of C3-plants and epidermal, mesophyll and bundle sheath tissues of C4-plants. Plant Physiology 82(2):503-10. PMID: 16665059

Berry JO, Nikolau BJ, Carr JP, Klessig DF. 1986. Translational regulation of light-induced ribulose-1,5-bisphosphate carboxylase gene expression in Amaranth. Molecular and Cellular Biology 6(7):2347-53. PMID: 3785198.

Berry JO, Nikolau BJ, Carr JP, Klessig DF. 1985. Transcriptional and post-transcriptional regulation of ribulose-1,5-bisphosphate carboxylase gene expression in light- and dark-grown Amaranth cotyledons. Molecular and Cellular Biology 5(9):2238-46. PMID: 3837189.

Nikolau BJ, Wurtele ES, Stumpf PK. 1985. Use of streptavidin to detect biotin-containing proteins in plants. Analytical Biochemistry 149(2):448-53. PMID: 2866733.

Wurtele ES, Nikolau BJ, Conn EE. 1985. Subcellular and developmental distribution of b-cyanoalanine synthase in barley leaves. Plant Physiology 78(2):285-90. PMID: 16664231.

Nikolau BJ, Wurtele ES, Stumpf PK. 1984. Subcellular distribution of acetyl-CoA carboxylase in mesophyl cells of barley and sorghum leaves. Archives of Biochemistry and Biophysics 235(2):555-61. PMID: 6151378.

Wurtele ES, Nikolau BJ, Conn EE. 1984. The tissue distribution of beta-cyanoalanine synthase in leaves. Plant Physiology 75(4):979-82. PMID: 16663772.

Nikolau BJ, Wurtele ES, Stumpf PK. 1984. Tissue distribution of acetyl-coenzyme A carboxylase in leaves. Plant Physiology 75(4):895-901. PMID: 16663756.

Nikolau BJ, Hawke JC. 1984. Purification and characterization of maize leaf acetyl-CoA carboxylase. Archives of Biochemistry and Biophysics 228(1):86-96. PMID: 6141767.

Sanchez J, Nikolau BJ, Stumpf PK. 1983. Reduction of N-acetyl methionine sulfoxide in plants. Plant Physiology 73(3):619-23. PMID: 16663269.

Nikolau BJ, Hawke JC, Slack CR. 1981. Acetyl-Coenzyme A carboxylase in maize Leaves. Archives of Biochemistry and Biophysics 211(2):605-12. PMID: 6118096.

 

Invited Publications

MSI Board Members, Sansone SA, Fan T, Goodacre R, Griffin JL, Hardy NW, Kaddurah-Daouk R, Kristal BS, Lindon J, Mendes P, Morrison N, Nikolau B, Robertson D, Sumner LW, Taylor C, van der Werf M, van Ommen B, Fiehn O. 2007. The metabolomics standards initiative. Nat Biotechnol. 25(8):846-8. PMID: 17687353.

Jenkins H, Hardy N, Beckmann M, Draper J, Smith AR, Taylor J, Fiehn O, Goodacre R, Bino RJ, Hall R, Kopka J, Lane GA, Lange BM, Liu JR, Mendes P, Nikolau BJ, Oliver SG, Paton NW, Rhee S, Roessner-Tunali U, Saito K, Smedsgaard J, Sumner LW, Wang T, Walsh S, Wurtele ES, Kell DB. 2004. A proposed framework for the description of plant metabolomics experiments and their results. Nature Biotechnology 22(12):1601-6. PMID: 15583675.

Bino RJ, Hall RD, Fiehn O, Kopka J, Saito K, Draper J, Nikolau BJ, Mendes P, Roessner-Tunali U, Beale MH, Trethewey RN, Lange BM, Wurtele ES, Sumner LW. 2004. Potential of metabolomics as a functional genomics tool. Trends in Plant Sciences 9(9):418-25. 9(9):418-25. PMID: 15337491.

Nikolau BJ, Ohlrogge JB, Wurtele ES. 2003. Plant Biotin-Containing Carboxylases. Archives of Biochemistry and Biophysics. Minireview. Archives of Biochemistry and Biophysics 414(2):211-22. PMID: 12781773.

Oliver DJ, Nikolau BJ, Wurtele ES. 2002. Functional Genomics: High throughput mRNA, protein, and metabolite analyses. Metabolic Engineering 4(1):98-106. PMID: 11800579.

Wurtele ES, Nikolau BJ. 2000. Characterization of 3-methylcrotonyl-CoA carboxylase from plants. Methods in Enzymology 324:280-92. PMID: 10989437.

Schnable PS, Hsia AP, Nikolau BJ. 1998. Genetic Recombination in Plants. Current Opinions in Plant Biology 1(2):123-9. PMID: 10066571.

Schnable PS, Xu XJ, Civardi L, Xia YJ, Hsia AP, Zhang L, Nikolau BJ. 1996. The role of meiotic recombination in generating novel genetic variability. In The Impact of Plant Molecular Genetics (B.W.S. Sobral, ed). Birkhäuser Press, Boston, pp 103-110.

Schnable PS, Nikolau BJ, Stinard PS, Xia Y, Hansen JD, Xu X, Delledonne M, Myszewski ME. 1993. Genetic approaches to isolating maize and Arabidopsis genes involved in cuticular wax biosynthesis. In Biochemistry and Molecular-Biology of Membrane and Storage Lipids of Plants. (N. Murata and C. Somerville, eds.) American Society of Plant Physiologists Press, pp. 196-206.

Nikolau BJ, Wurtele ES, Caffrey J, Chen Y, Crane V, Diez T, Huang JY, Mc Dowell MT, Shang XM, Song J, Wang X, Weaver LM. 1993. The biochemistry and molecular biology of acetyl-CoA carboxylase and other biotin enzymes. In Biochemistry and Molecular-Biology of Membrane and Storage Lipids of Plants. (N. Murata and C. Somerville, eds.) American Society of Plant Physiologists Press, pp. 138-149.

Schnable PS, Wise R, Nikolau BJ. 1992. Transposon tagging agronomically important loci in maize. Proceedings, 28th Annual Illinois Corn Breeder's School, pp. 24-45.

 

Proceedings Chapters

Perera MADN, Dietrich CR, MeeleyR, Schnable PS, Nikolau BJ. 2003. Dissecting the maize epicuticular wax biosynthetic pathway via the characterization of an extensive collection of glossy mutants. In Advanced Research on Plant Lipids. (eds. M Murata, M Yamada, I Nishida, H Okuyama, J Sekiya, W Hajima, H Wada) Kluwer Academic Press, Boston, pp. 225-228.

Fatland B, Anderson M, Nikolau BJ, Wurtele ES. 2000. Molecular biology of cytosolic acetyl-CoA generation. The Proceedings of the 14th International Symposium on Plant Lipids, Cardiff, Wales. Biochemical Society Transactions 28:593-595.

Nikolau, BJ, Oliver DJ, Schnable PS, Wurtele ES. 2000. Molecular biology of acetyl-CoA metabolism. The Proceedings of the 14th International Symposium on Plant Lipids, Cardiff, Wales. Biochemical Society Transactions 28:591-593.

Wurtele ES, Nikolau BJ, Schnable PS, Oliver DJ, Ke J, Behal RH. 1999. Molecular Biology of Acetyl-CoA Generation. Proceedings of the 13th International Symposium on Plant Lipids, Sevilla, Spain. J. Sanchez, ed. Kluwer Press. pp. 54-56.

Nikolau BJ, Ke J, Choi JK, Wurtele ES. 1999. In situ and transgenic studies of the regulation of acetyl-CoA carboxylase gene expression. Proceedings of the 13th International Symposium on Plant Lipids, Sevilla, Spain. J. Sanchez, ed. Kluwer Press. pp. 50-53.

Choi JK, Ke J, McKean AL, Weaver LM, Wen TN, Sun J, Diez T, Yu F, Guan X, Wurtele ES, Nikolau BJ. 1997. Molecular biology of biotin-containing enzymes required in lipid metabolism. In Physiology, Biochemistry and Molecular Biology of Plant Lipids. (J.P. Williams, M.U. Khan, N.W. Lem eds.). Kluwer Academic Publishers, pp. 363-367.

Hansen JD, Dietrich C, Xia Y, Xu X, Wen TJ, Delledonne M, Robertson DS, Schnable PS, Nikolau BJ. 1997. Molecular biology of genes involved in cuticular wax biosynthesis. In Physiology, Biochemistry and Molecular Biology of Plant Lipids. (J.P. Williams, M.U. Khan, N.W. Lem eds.). Kluwer Academic Publishers, pp. 336-338.

Nikolau BJ, Xu X, Xia Y, Hansen, Heinen S, Wen TJ, Delledonne M, Schnable PS. 1995. Molecular cloning and characterization o Jf genes involved in cuticular wax biosynthesis. In Plant Lipid Metabolism. (J-D. Kader and P. Mazliak eds.). Kluwer Academic Publishers, pp. 127-130.

Nikolau BJ, Caffrey JJ, Diez T, Huang JY, Shang XM, Weaver LM, Wurtele ES. 1995. Biochemical and molecular biological characterization of acetyl-CoA carboxylases. In Plant Lipid Metabolism. (J-D. Kader and P. Mazliak eds.). Kluwer Academic Publishers, pp. 39-42.

Caffrey JJ, Chen Y, Diez T, Guan X, Huang JY, McKean A, Song J, Shang XM, Wang, Weaver LM, Wurtele ES, Nikolau BJ. 1995. Biochemical and molecular biological chara Xcterization of biotinylated proteins of plants. In Plant Lipid Metabolism. (J-D. Kader and P. Mazliak eds.). Kluwer Academic Publishers, pp. 49-51.

Nikolau BJ, Croxdale J, Ulrich TH, Wurtele ES. 1987. Acetyl-CoA carboxylase and biotin-containing proteins in carrot somatic embryogenesis. In Metabolism Structure and Function of Plant Lipids (P.K. Stumpf, J.B. Mudd, and W.D. Nes, eds.), Plenum Press, NY, pp. 517-519.

 

Book

B.J. Nikolau and E.S., Wurtele (editors). 2007. Concepts in Plant Metabolomics. Springer Press. A 21 chapter, 355-page edited book, published in 2007 (ISBN-10: 1-4020-5607-9).