Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology

Nikolau Group - Postdoctoral Research Associates

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Contact us at
nikolau.research@iastate.edu

Postdoctoral Research Associates

(listed alphabetically)

Geng DING photo

Rupam BHUNIA

Publications

Research project summary: Understanding the cutin structure of plant cells

Hometown: Gidhni, West Bengal, India. Degrees: B.Sc in Microbiology, Vidyasagar University, India; M.Sc in Applied Microbiology, VIT, India; PhD in Plant Biotechnology, Indian Institute of Technology (IIT), Kharagpur, India. Thesis title: Genetic engineering of fatty acid biosynthetic pathway to improve the nutritional quality of sesame oil. Likes best about working with the Nikolau group: People are friendly, and ready to help at any time. Fun fact: I am passionate about playing cricket and have been match-winner for my team many times. Bonus Fact: I am a big foodie and love eating chicken.


Xin GUAN photo

Xin GUAN

Publications

Research project summary: 
Plant cells appear to have at least three fatty acid forming systems, which occur in distinct subcellular compartments: plastids, mitochondria, and the ER membrane. The mitochondrial fatty acid synthase (mtFAS) is a Type II system that utilizes dissociated enzymes to catalyze the iterative reactions for fatty acid production. My research project is to identify and characterize genes that encode enzymes of Arabidopsis mtFAS system. I am applying interdisciplinary strategies (i.e., biochemistry, plant manipulation, metabolomics, and RNA-seq) to investigate the biochemical and physiological functions of Arabidopsis mtFAS system. In addition, I am trying to introduce the mtFAS components into heterologous systems for the production of fatty acid-derived biorenewable chemicals. Finally, I am developing new metabolomics methodologies that formulate data-driven hypotheses on the gene functions and guide the metabolic engineering. 

Hometown: Jinan, Shandong Province, China. Degree: BS in Biotechnology, Shandong University, China (2007); PhD in Biochemistry, Iowa State University (2014). Thesis title: Enzymatic components and physiological roles of mitochondrial fatty acid biosynthesis in plants. Research interests: Fatty acid and lipid metabolism, metabolomics, and metabolic engineering. Likes best about working with the Nikolau group: The friendly people and various research fields in the Nikolau group encourage me to learn and think.


Fuyuan JING photo

Fuyuan JING

Publications

Research project summary: Acyl-ACP thioesterases are the enzymes that terminate acyl-chain elongation in fatty acid biosynthesis. The objective of my project is to identify or develop novel acyl-ACP thioesterases that have the ability to terminate the fatty acid chain elongation at 6-carbon to 8-carbon chain length or have flexibility to hydrolyze a substituted acyl-thioesters. Currently I am conducting functional/structural studies of acyl-ACP thioesterases with different substrate specificities. Later, both rational design and random mutagenesis will be used to obtain novel thioesterases.

Hometown: Hubei Province, China. Degrees: MS in Botany, Shanghai Jiaotong University, Shanghai, China; PhD in Biochemistry, Iowa State University. Thesis title: Characterization of acyl-ACP thioesterases for the purpose of diversifying fatty acid synthesis pathway. Likes best about working with the Nikolau group: Working on my project. Fun fact: I like basketball and tennis.


Ryan STURMS photo

Ryan STURMS

Publications

Research project summary: I am currently working on an Iowa Energy Center project to characterize the lubrication properties of omega-hydroxylated fatty acids. The goal of this work is to demonstrate superior lubrication properties of novel bi-functional fatty acids.

Hometown: Muscatine, Iowa. Degrees: BS in Agricultural Biochemistry, Iowa State University; PhD in Biochemistry, Iowa State University. Thesis title: Structure and function of class one non-symbiotic plant hemoglobins. Research interests: Protein structure/function relationships. Looking forward to while working with the Nikolau group: I am most looking forward to applying the knowledge and skills I have to a project that could bring about a change in the way a consumer product is made. Fun fact: Since being diagnosed with Celiac disease in 2014, my wife and I have both become quite good GF home cooks and can make many dishes with GF equivalents.


Bryon UPTON photo

Bryon UPTON

Research project summary: I am researching biotin dependent carboxylases from Arabidopsis thaliana, specifically heteromeric acetyl-CoA carboxylase and 3-methylcrotonyl-CoA carboxylase. My goal is to understand the structural/functional significance of alternative splicing and gene isoforms within these enzymes. This may lead to the understanding and development of novel catalysts to be implemented into bioengineered metabolic pathways.

Hometown: Burlington, Iowa. Degrees: BS in Biochemistry, Iowa State University; PhD in Biochemistry, Iowa State University. Thesis title: Biochemical characterization of the biotin-dependent carboxylases, acetyl-CoA
carboxylase and 3-methylcrotonyl-CoA carboxylase. Research interests: Enzyme structure/function relationships. Likes best about working with the Nikolau group: Interacting with so many intelligent people. Fun fact: I enjoy the Cubs and everything that is Chicago (except for the White Sox).