beginning of the study, all participants will be asked to complete
a medical history. A physical exam will be performed by the study
physician, and a physician-supervised maximal exercise test on a
treadmill will be administered to determine whether it is safe for
participants to exercise. As a participant in this study, you may
be assigned to either an aerobic exercise group or a flexibility/balance
group for a one-year period. You will not have a choice regarding
group assignment. However, those individuals assigned to the flexibility/balance
group for one year will have the option of participating in an aerobic
exercise program (free of charge) for one year following completion
of the study. Individuals in the aerobic exercise group will be
asked to participate in supervised exercise sessions, using exercise
bicycles, treadmill, rowing machines, and/or stair steppers, three
times per week, approximately 30 - 40 minutes per session. Individuals
in the flexibility/balance will meet three times per week to participate
in appropriate activities.
As a participant, you will be asked to give a blood sample a total
of 12 times in a 17-18 month period. Approximately 40 ml of blood
(less than 3 ounces) of blood will be drawn from a forearm vein
each time. Your body contains approximately 5000 ml of blood; therefore,
we will be removing approximately 1% of your total blood volume
with each sample. At the start of the study, you will receive the
year 1 influenza immunization (fall 2002). Blood samples will be
taken two times before this immunization and at 4 time points throughout
the flu season after the immunization.
After year one the second influenza immunization will be administered
(fall 2004). Two blood samples will be taken before the year two
immunization and again at 4 time points following the vaccination.
We ask that all participants continue to attend exercise sessions
for up to 6 months following immunization number two.
As a participant in this study, we will also ask you to complete
a dietary questionnaire and psychosocial questionnaires. We will
ask you several questions about your exercise habits and ask you
to perform fitness tests for older adults. This information will
remain confidential. You may withdraw your consent to participate
at any time throughout the study. Such withdrawal can be for any
reason you choose.
Your questions on any aspect of this research are welcome. At the
conclusion of this study, you will be informed of the results of
this study. Your results will be kept strictly confidential and
should your data be used in publication of the results, your name
or any identifying characteristic will not be used.
To apply for the study or to request more information please mail
or email your name and address
to the Primary Investigator at: