Research Experience

    Graduate Research Assistant, Iowa State University   (2011-Present)
    - Understanding dynamics from protein structre pairs and ensembles
    - Development of a coarse grained elastic network model for membrane proteins to predict their dynamics
    - Classified and quantified conformational changes in RNA binding proteins with applications to interface prediction & docking.

    Trainee, National Centre for Biological Sciences (NCBS), Bangalore   (2010-2011)
    - Designed a sequence & structure based scoring scheme for analyzing the conservation of ligand binding sites in mosquito odorant binding proteins and serine proteases followed by docking to identify potential drugs.
    - Developed an algorithm called DockScore (in Perl) for scoring docking predictions of protein-protein complexes such as antigen-antibody complexes. This score picked native complexes with greater accuracy than existing methods.
    - Homology modelled Olfactory Receptors (ORs) (using MODELLER) from selected eukaryotic genomes and analyzed structurally conserved residues.
    - Developed Perl based software (using PerlTk \& BioPerl) called TM-MOTIF for the interactive visualization of transmembrane regions and motifs in G-Protein Coupled Receptors (GPCRs).

    Trainee, Indian Institute of Science (IISc), Bangalore   (Summer 2009)
    - Expressed the mycobaterial protein Rv0805 (a phosphodiesterase) in E. coli, purified it using Ni/NTA-His tag chromatography \& FPLC and characterized it for its hydrolytic activity using various biochemical assays and autoradiography