-- Research: HIF Project
-- Research: AHR Project
-- Photo Gallery
The Powell-Coffman Lab is in the Department of Genetics, Development, and Cell Biology at Iowa State University. Our research group employs a powerful genetic model system, the nematode C. elegans, to study how animals sense and adapt to their environment. Currently, our research is focused on two biomedically important transcription factors: the aryl hydrocarbon receptor (AHR) and the hypoxia-inducible factor (HIF). The laboratory is located on the second floor of the Molecular Biology Building (shown above). Please follow the links in the left column of this page for information on our research projects and publications.
Jo Anne Powell-Coffman
Department of Genetics, Development & Cell Biology
2108 Molecular Biology Building
Iowa State University
Ames IA 50011-3260
Phone: (515) 294-3906
Fax: (515) 294-6755
RHY genes: regulators of hypoxia-inducible factor activity
In animals, the hypoxia-inducible factor plays a central role in the response to hypoxia (low oxygen). Using genetic strategies in C. elegans, we have identified novel regulators of HIF-1 and have gained important insights to the regulatory circuits that control HIF-1. Shen et al. (2006) Genetics 174, 1205
Links between the dioxin receptor and behavior
In mammals, the toxic effects of dioxins are mediated by the aryl hydrocarbon receptor (AHR). We have shown that AHR activity in key neurons is required for a specific behaviors in C. elegans. Qin et al. (2006) Dev Biol 298, 20580 Interestingly, other research groups have shown that this behavior can also be suppressed by lowering the level of oxygen in the environment.