Tim Day's Lab

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Curriculum Vitae


Tim A. Day
Assistant Professor
Department of Biomedical Sciences
Iowa State University, Ames, IA 50011

Phone: (515) 294-7100
Fax: (515) 294-2315
E-mail: day@iastate.edu

 

Professional Experience


2000 - Assistant Professor
Department of Biomedical Sciences, Iowa State University, Ames, IA
2002 - Chairman
Neuroscience Program, Iowa State University, Ames, IA  
2000 -  Faculty
Neuroscience Program, Iowa State University, Ames, IA  
2001 -  Faculty
Toxicology Program, Iowa State University, Ames, IA
1997 - 2000  Assistant Professor
Department of Pharmacology & Toxicology, Michigan State University, East Lansing, MI
1996 - 1997 Visiting Assistant Professor
Department of Zoology, Michigan State University, East Lansing, MI
1994 - 1996 Field Representative
Resource Exchange International, Hanoi Medical College, Hanoi, Vietnam 
1993 - 1994 Post-Doctoral Research Associate
Department of Pharmacology & Toxicology, Michigan State University, East Lansing, MI
1991 - 1993  Pre-Doctoral Research Assistant
Department of Zoology, Michigan State University, East Lansing, MI
1989 - 1991  Pre-Doctoral Research Assistant
Department of Pharmacology & Toxicology, Michigan State University, East Lansing, MI
1988 - 1989 Pre-Doctoral Research Fellow
College of Natural Science, Michigan State University, East Lansing, MI

Education


1993 Ph.D.
Pharmacology & Toxicology, Michigan State University
1990  M.S.
Zoology, Michigan State University  
1990  B.S.
Education, Michigan State University
1988  B.S.
Biology, Kansas State University

Professional Affiliations


British Society for Parasitologists
  American Society for Parasitologists 
American Society of Tropical Medicine & Hygiene
Society for Neuroscience

Service to the Professional Community


2000 - 2003 Editorial Board
Parasitology, Cambridge University Press
2000 - Study Section
National Institutes of Health, Tropical Medicine & Parasitology, Temporary ad hoc Member
 
  Ad hoc Reviewer
American Journal of Tropical Medicine & Hygiene
Biochemical Pharmacology
Experimental Parasitology
International Journal for Parasitology
Journal of Parasitology
Journal of Comparative Physiology
Molecular and Biochemical Parasitology
Molecular Neurobiology
Neurotoxicology
Peptides
Proceedings of the National Academy of Sciences
Southern Medical Journal
 

Service to the University Community


2003 - Student Awards Committee
College of Veterinary Medicine, Iowa State University
2001 - Faculty Governance Committee
College of Veterinary Medicine, Iowa State University
2001 - 2002 Pharmacology/Phsyiology Search Committee (3 positions)
Department of Biomedical Sciences, Iowa State University
2001 - 2004 Neuroscience Program Supervisoty Committee
Neuroscience Program, Iowa State University
2001 - 2004 Graduate Admissions Committee, Chair
Neuroscience Program, Iowa State University 
2000 - 2003 Research Advisory Council
College of Veterinary Medicine, Iowa State University
2003 Research Advisory Council Subcommittee
Review of University Bailey Research Award Grants
2003 Research Advisory Council Subcommittee
Review of University Reserach Grant Proposals
2002 Research Advisory Council Subcommittee
Review of 2002-2003 USDA Formula Funds Proposals
2002 Research Advisory Council Subcommittee
Chair, Review of 2002-2003 HLI (Healthy Livestock Initiative) Proposals
2001 Research Advisory Council Subcommittee
Assessment and Re-evaluation of College of Veterinary Medicine Intramural Research Funding Programs
2001 Research Advisory Council Subcommittee
Review of 2001-2002 HLI (Healthy Livestock Initiative)
Proposals
 
2001 Research Advisory Council Subcommittee
Review of 2001-2002 IHLAC (Iowa Healthy Livestock Advisory Council) Proposals
 
2001 Research Advisory Council Subcommittee
Review of 2001-2002 USDA Formula Funds Proposals
2000 Research Advisory Council Subcommittee
Review of 2000-2001 IHLAC (Iowa Healthy Livestock Advisory Council) Contingency Proposals
2000 Research Advisory Council Subcommittee
Review of 2000-2001 USDA Formula Fund Proposals
1998 - 2000 Committee Serving Under-Represented Minorities
Department of Pharmacology & Toxicology, Michigan State University

Teaching Experience


2003 - Cellular, Molecular and Developmental Neurobiology, Lecturer
NEURO/BMS 556, Iowa State University
2002 -   General Principles of Pharmacology, Lecturer
BMS 354/554 General Pharmacology, Iowa State University
2002 - Autonomic Pharmacology, Lecturer
BMS 354/554 General Pharmacology, Iowa State University 
2001 - Circulation of Specialized Regions, Lecturer
BMS 552 Physiology, Iowa State University
1999   Antiparasitic Agents, Lecturer
PHM 820 Cellular & Molecular Pharmacology, Michigan State University
1998 Veterinary Parasitology, Lecturer
PHM 556 Veterninary Pharmacology, Michigan State University
1996 - 1997 Neurobiology, Course Coordinator & Lecturer
ZOL/PSL 402 Neurobiology, Michigan State University
1996 - 1998 Passive Properties of Biological Membranes, Lecturer
PHM 827 Physiology & Pharmacology of Excitable Cells, Michigan State University
1991 - 1998 Renal Toxicology, Lecturer
PHM 450 Toxicology, Michigan State University
1991 - 1992  Potassium Channels, Lecturer
ZOL/PSL 827 Neurobiology, Michigan State University
1989  Comparative Neurobiology, Graduate Assistant
ZOL 827 Comparative Neurobiology, Michigan StateUniversity
1990  General Biology, Student Teacher
Portland High School, Portland, MI
1990 Earth Science, Student Teacher
Portland High School, Portland, MI
1986 - 1987 Pre-College Algebra, Course Instructor
Kansas State University

Research Funding


2002 - 2003 Exploring New Control Strategies in Soybean Cyst Nematodes
Role: Principal Investigator
Funding Agency: Iowa State University
Type of Proposal: University Research Grant
Direct Costs / Duration: $18,000 / 1 yr.
2002 - 2004  Exploring New Drug Targets in Parasitic Helminths
Role: Principal Investigator
Funding Agency: Healthy Livestock Initiative of Iowa
Type of Proposal: Position Support Grant
Direct Costs / Duration: $62,500 / 2.5 yrs
 
2000 - 2004 Structure and Function of Schistosome Neuropeptide F
Role: Principal Investigator
Funding Agency: NIH/NIAID Tropical Medicine & Parasitology
Type of Proposal: R01
Direct Costs / Duration: $700,000 / 4 yrs.
1998 - 2001 Resistance to Praziquantel: An Emerging Problem
Role: Co-Investigator
Funding Agency: NIH/NIAID Tropical Medicine & Parasitology
Type of Proposal: R01
Direct Costs / Duration: $1,329,967 / 3 yrs.
1998  Structure & Function of FMRFamide-Related Peptide Receptors
Role: Principal Investigator
Funding Agency: Pharmacia & Upjohn
Direct Costs / Duration: $25,000 / 1 yr.
1998 - 2000  Praziquantel Resistance in Egypt
Role: Visiting Expert
Agency: World Health Organization - TDR
Type of Proposal: Research Capability Strengthening Grant
Direct Costs / Duration: $98,900 / 3 yrs.
1995 - 1999 Analysis of Ion Channels in S. mansoni Muscle Fibers
Role: Co-Investigator
Funding Agency: NIH/NIAID Tropical Medicine & Parasitology
Type of Proposal: R01
Direct Costs / Duration: $581,987 / 4 yrs.

Invited Seminars



2002 Schistosomiasis in Egypt: Morbidity Control and the Emergence of Resistance
Toxicology Program, Iowa State University, Ames, IA
2002 Schistosomiasis in Egypt: Morbidity Control and the Emergence of Resistance
Department of Veterinary Pathology, Iowa State University, Ames, IA
2001 Pharmacology of Schistosomes: Serotonin and Neuropeptides
Schistosomiasis Congress, Recife, Brazil
2001 Figuring Out Flukes: The Current State of Schistosomiasis Research
Department of Biochemistry and Biology, Queen's University of Belfast, Belfast, Northern, Ireland.
2001 The Potential of Resistance to Praziquantel in Egypt
Department of Biomedical Sciences, Iowa State University, Ames, IA
2001 Resistance to Praziquantel
Keystone Symposium: Molecular Helminthology, An Integrated Approach, Taos NM
2000 Neurotransmission in Parasitic Worms
Neuroscience Program, Iowa State University, Ames IA
2000  Exploring New Drug Targets. How will the Next Generation of Anthelmintic Drugs be Discovered?
Department of Biology, Cayey University, Cayey, Peurto Rico
1999  Neuropeptides in Parasitic Platyhelminths
Department of Biomedical Sciences, Iowa State University, Ames, IA
1999 Neuropeptides in Parasitic Platyhelminths
Center for Tropical and Emerging Global Diseases, Univ. of Georgia, Athens, GA
1999 People, Parasites and Peptides
Department of Biology, University of Alaska Anchorage, Anchorage, AK
1999 People, Parasites and Peptides
Department of Biology, University of Central Arkansas, Conway, AR
1998  Peptidergic Transmission in Parasitic Platyhelminths
Department of Biology, University of Toledo, Toledo, OH
1996 FMRFamide-like Peptides in Schistosomes
Keystone Symposium: Molecular Helminthology, An Integrated Approach

Publications



2003 A functionally atypical amidating enzyme from the human parasite Schistosoma mansoni. G.R. Mair, M.J. Niciu, M.T. Stewart, G. Brennan, H.H. Omar, D.W. Halton, R. Mains, B.A. Eipper, A.G. Maule and T.A. Day. FASEB Journal, in press.    
2003 Muscle organisation of Schistosoma mansoni ceracria. G.R. Mair, A.G. Maule, B. Fried, T.A. Day and D.W. Halton, Journal of Parasitology, in press    
2002 Neuropeptide F (NPF) from the land planarian, Arthurdendyus triangulatus: gene organisation and expression (2002). P.M. Dougan, G.R. Mair, D.W. Halton, W.J. Curry T.A. Day and A.G. Maule. Journal of Comparative Nuerology 454:58-64.  
2002 Functional voltage-gated Ca2+ channels in muscle fibers of the Platyhelminth Girardia tigrina (2002). P. Cobbett and T.A. Day. Comparative Biochemistry and Physiology Part A 134:593-605.    
2002 Neuropeptide Signaling Systems - Potential Drug Targets for Parasite and Pest Control (2002). A.G. Maule, A. Mousley, N.J. Marks, T.A. Day, D.P. Thompson, T.G. Geary and D.W. Halton. Current Topics in Medicinal Chemistry 2:733-758.    
2001 Stability and reproductive fitness of S. mansoni isolates with decreased sensitivity to praziquantel (2001). S. William, A. Sabra, F. Ramzy, M. Mousa, Z. Demerdash, T.A. Day, J.L. Bennett and S. Botros. International Journal for Parasitology 31:1093-1100.    
2001 Cloning and characterization of a muscle isoform of a Sodium Potassium ATPase alpha subunit (SNaK1) from Schistosoma mansoni (2001). P.J. Skelly, P.M. Dougan, A.G. Maule, T.A. Day and C.B. Shoemaker. Parasitology 123:277-284.    
2001 Physiological effects of FMRFamide-related peptides and classical transmitters on isolated muscle fibres of the turbellarian Procerodes littoralis (2001). C.G. Moneypenny, N. Kreshchencko, T.A. Day, C. Moffett, D.W. Halton and A.G. Maule. Parasitology 122:447-455.    
2001 Praziquantel-induced tegumental damage in vitro is diminished in schistosomes derived from praziquantel-resistant infections (2001). S. William, S. Butros, M. Ismail, A. Farghally. T.A. Day and J.L. Bennett. Parasitology 122:63-66.    
2000 Confocal microscopal study of the musculature of adult Schistosoma mansoni (2000). G.R. Mair, A.G. Maule, T.A. Day and D.W. Halton Parasitology 121:163-170.    
2000 Functional ryanodine receptor channels in flatworm muscle fibres (2000). T.A. Day, J. Haithcock, M. Kimber and A.G. Maule. Parasitology 120:417-422.    
2000 Pharmacology of FMRFamide-related peptides (FaRPs) in helminths (2000). T.G. Geary, N.J. Marks, A.G. Maule, J.W. Bowman, S.J. Alexander-Bowman, T.A. Day, M.J. Larsen, T.M. Kubiak, J.P. Davis and D.P. Thompson. Annals of the New York Academy of Sciences 897:212-227.    
1999 Parasitic Peptides! The structure and function of neuropeptides in parasitic worms (1999). T.A. Day and A.G. Maule. Peptides 20:999-1019.    
1999 Resistance to praziquantel: direct evidence from parasites isolated from Egyptian villagers (1999). M. Ismail, A. Metwally, S. William, S. Botros, A. Farghally, L. Tao, T.A. Day, J.L. Bennett. American Journal of Tropical Medicine & Hygiene 60:932-935.    
1998 The metalloprotease inhibitor 1,10-phenanthroline affects Schistosoma mansoni motor activity, egg laying and viability (1998). T.A. Day and G.Z. Chen. Parasitology 116:319-325.   
1997 The development of resistance to anthelmintics: a perspective with an emphasis on the antischistosomal drug praziquantel (1997). J.L Bennett, T.A. Day, L. Tao, M. Ismail, A. Farghally, Experimental Parasitology 87:260-267.     
1997 Physiological effects of platyhelminth FMRFamide-related peptides (FaRPs) on the somatic musculature of the monogean Diclodophora merlangi (1997). C.G. Moneypenny, A.G. Maule, C. Shaw, T.A. Day, R.A. Pax and D.W. Halton, Parasitology 115:281-288.     
1997 Structure-activity relationships of FMRFamide-related peptide-induced contractions of Schistosoma mansoni muscle (1997). T.A. Day, A.G. Maule, C. Shaw, and R.A. Pax, Peptides 18:917-921.     
1996 Neurobiology of Helminth Parasites (1996). A.G. Maule, D.W. Halton, T.A. Day, R.A. Pax and C. Shaw. Chapter 6, Analytical Parasitology, Eds: M.T. Rogan & P.S. Craig, Heidelberg: Springer-Verlag.    
1996 Neuromuscular physiology and pharmacology of parasitic flatworms (1996). R.A. Pax, T.A. Day, C.L. Miller and J.L. Bennett, Parasitology 113:S83-S96.     
1996 S. mansoni: L-glutamate-induced contractions in isolated muscle fibers; evidence for a glutamate transporter (1996). C.L. Miller, T.A. Day, J.L. Bennett and R.A. Pax, Experimental Parasitology 84:410-419.     
1996 Cholinergic inhibition of muscle fibres isolated from Schistosoma mansoni (Trematoda: Digenea) (1996). T.A. Day, G.Z. Chen, C. Miller, M. Tian, J.L. Bennett and R.A. Pax, Parasitology 113:55-61.     
1995 Analysis of the kinetics and voltage-dependency of transient and delayed K+ currents in muscle fibers isolated from the flatworm Schistosoma mansoni (1995). T.A. Day, E. Kim, J.L. Bennett and R.A. Pax, Comparative Biochemistry and Physiology 111A:79-87.     
1995 Immunohistochemical localisation of a Shaker-related potassium channel protein in Schistosoma mansoni (Trematoda: Digenea)(1995). E. Kim, T.A. Day, N.J. Marks, R.N. Johnston, D.W. Halton, C. Shaw, G.Z. Chen, J.L. Bennett and R.A. Pax, Experimental Parasitology 81:421-429.     
1995 Cloning and functional expression of a Shaker-related voltage-gated potassium channel gene from the flatworm Schistosoma mansoni (Trematoda: Digenea) (1995). E. Kim, T.A. Day, J.L. Bennett and R.A. Pax, Parasitology 110:171-180.     
1994 Platyhelminth FMRFamide-related peptides (FaRPs) contract Schistosoma mansoni (Trematoda: Digenea) muscle fibres in vitro (1994). T.A. Day, A.G. Maule, C. Shaw, D.W. Halton, S. Moore, J.L. Bennett and R.A. Pax, Parasitology 109:455-459.     
1993 Serotonin and its requirement for contractility in muscle fibres isolated from Schistosoma mansoni (1994). T.A. Day, J.L. Bennett and R.A. Pax, Parasitology 108:425-432.     
1993  Voltage-gated currents in muscle cells of Schistosoma mansoni (1993). T.A. Day, N. Orr, J.L. Bennett and R.A. Pax, Parasitology 106:471-477.     
1992 Praziquantel: The enigmatic antiparasitic (1992). T.A. Day, J.L. Bennett and R.A. Pax, Parasitology Today 8:342-344.     
1992  Schistosoma mansoni: Patch-clamp study of a non-selective cation channel in the outer tegumental membrane of females (1992). T.A. Day, M.L. Lewis, J.L. Bennett and R.A. Pax, Experimental Parasitology 74:348-356.     
1991 Studies on muscle cells isolated from Schistosoma mansoni: A calcium-dependent potassium channel (1991). K.L. Blair, T.A. Day, M.L. Lewis, J.L. Bennett and R.A. Pax, Parasitology 102:251-258.    

Presentations at National and International Meetings

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