Tim Day's Lab

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Structure and Function of Neuropeptides in Flatworms

Our understanding of flatworm neurobiology has been very defiecient. One reason for this is that studies of the nervous system of flatworms have been limited almost exculsively to amine-based transmitters like serotonin, acetylcholine, etc. It is now clear that only a small fraction of flatworm neurobiology can be understood in terms of these transmitters. Yet unexplorted is the role of neuropeptides, even though neuropeptides are the most abundant neuromediators in these animals. Investigations of the peptidergic components of these early nervous systems will undoubtedly illuminate the development of early neuromuscular systems and might uncover targets for novel anti-parasitic drugs.

Ion Channels in Nerve and Muscle of Flatworms

Ion channels are what make neuromuscular systems work! So, we continue studies of the ion channels of parasite neuromuscular systems. These studies will likewise illuminate the development of early neuromuscular systems and, likewise, might uncover targets for novel anti-parasitic drugs.

Praziquantel Resistance Among Schistosomes in Egypt

Schistosomes are (by far) the most important flatworm parasite, afflicting over 200 million people. Praziquantel is the only drug available to treat schistosomiasis in many parts of the world. Unfortunately, resistance to praziquantel may be emerging among schistosomes.

 

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