Igor I. Slowing
Fall 2003 - April 2008: Ph.D. in Chemistry, Iowa State University, USA, with Prof. Victor Lin.
1988 - 1995: License Degree in Chemistry from San Carlos University in Guatemala.
My work is focused on the functionalization and structural design of mesoporous silica nanoparticles (MSN) for studying their interactions with live cells. Besides of trying to improve the abilities of MSN as a drug/biomolecule delivery system, we are trying to understand the way MSN are taken up by cells, and their intracellular processing. The latter might allow us not only to achieve a new way of controlling cell metabolism but also to provide a new tool to use in the quest to understand some more the wonderful chemistry that occurs within life.
Trewyn, Brian G.; Slowing, Igor I.; Giri,Supratim; Chen, Hung-Ting; Lin, Victor S.-Y. "Synthesis and Functionalization of a Mesoporous Silica Nanoparticle Based on the Sol–Gel Process and Applications in Controlled Release." Accounts of Chemical Research, 2007, 40, 846-853.
Trewyn, Brian G.; Giri, Supratim; Slowing, Igor I.; Lin, Victor S.-Y. "Mesoporous silica nanoparticle based controlled release, drug delivery, and biosensor systems." Chemical Communications, 2007, 31, 3236-3245.
Slowing, Igor I.; Trewyn, Brian G.; Lin, Victor S.-Y. "Mesoporous Silica Nanoparticles for Intracellular Delivery of Membrane-Impermeable Proteins." Journal of the American Chemical Society , 2007, 129, 8845.
Slowing, Igor I.; Trewyn, Brian G.; Giri, Supratim; Lin, Victor S.-Y. "Mesoporous silica nanoparticles for drug delivery and biosensing applications." Advanced Functional Materials, 2007, 17, 1225.
Slowing, Igor; Trewyn, Brian G.; Lin, Victor S.-Y. "Effect of Surface Functionalization of MCM-41-Type Mesoporous Silica Nanoparticles on the Endocytosis by Human Cancer Cells." Journal of the American Chemical Society, 2006, 128, 14792.
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FITC labeled MSN grafted with a mitochondria targeting group, endocytosed by HeLa cancer cells. The nuclei are stained blue, and the mitochondria are stained red.