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2009-2011 Courses and Programs

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Toxicology

400 |Graduate Courses |500 |600 |

www.toxicology. iastate.edu

 toxmajor@iastate.edu

(Interdepartmental Graduate Major)

Supervisory Committee: A. Kanthasamy, Chair; J. Coats, A. Kanthasamy, R. Martin, P. Murphy, G. Osweiler

Toxicology is the science of studying the adverse effects of substances on living organisms. Students observe, gather data and predict risks and outcomes in populations. Whole organism research and cellular and molecular approaches are used to determine toxicant exposure and mechanisms. Work is offered for the degrees doctor of philosophy and master of science. Students majoring in toxicology will be affiliated with one of the following cooperating departments: Agricultural and Biosystems Engineering; Animal Science; Biochemistry, Biophysics and Molecular Biology; Biomedical Sciences; Chemistry; Entomology; Food Science and Human Nutrition; Genetics, Development and Cell Biology; Geological and Atmospheric Sciences; Natural Resource Ecology and Management; Physics; Plant Pathology; Veterinary Diagnostic and Production Animal Medicine; Veterinary Microbiology and Preventive Medicine; and Veterinary Pathology.

The prerequisites for entrance into the graduate toxicology major include an undergraduate degree in a relevant area of study; for example, chemical engineering, biology, biochemistry, chemistry, ecology, entomology, food science and technology, microbiology, nutritional science, zoology, or veterinary medicine. Minimum undergraduate coursework should include the following or their equivalent: 1 year of college mathematics, including calculus; 1 year of inorganic chemistry with quantitative analysis; 1 course in physics; 1 year of organic chemistry; 2 years of biological sciences including 1 course in physiology.

Other courses that are considered desirable in undergraduate preparation include: biochemistry, physical chemistry, qualitative analysis, and some specialized courses such as histology or advanced physiology.

Facilities and faculty are available for fundamental research in such areas as environmental fate and effects of chemicals, insect toxicology, aquatic toxicology, food safety, nutritional toxicology, mycotoxins, neurotoxicology, cellular and molecular toxicology and veterinary toxicology.

Students majoring in toxicology will be affiliated with a cooperating department. All Ph.D. students take a core curriculum consisting of Tox 501 and 502, Tox 504 (Toxicology Seminar, taken twice); 7 additional credits in toxicology; 8 credits in biochemistry from BBMB 404, 405, 420, 451, 542; 3 graduate credits in physiology, histology, pathology, neuroscience, immunobiology or cellular and molecular biology; and Stat 401 and 402. M.S. students take a core of Tox 501, 502, 504; 3 additional credits in toxicology; BBMB 404, 405; and Stat 401. Additional coursework is selected to meet departmental requirements and to satisfy individual student research interests.

A graduate minor in toxicology is available for students enrolled in other majors. A minor for an M.S. degree includes Tox 504 and 501 and 3 credits in other toxicology courses. A minor at the Ph.D. level includes Tox 504, 501, and 6 credits in other toxicology course work. One member of the student's program of study committee will be a member of the toxicology faculty.

Most students awarded doctoral degrees continue their training as postdoctoral associates at major research institutions in the U.S. or abroad in preparation for research and/or teaching positions in academia, industry, the military, veterinary research, or government environmental and public health institutions. A few go directly to permanent research positions in industry. Many students awarded master's degrees continue their training as doctoral students; however, some choose research support positions (i.e., technician, chemist, research associate) in academia, industry, or government. A more thorough list of outcomes is available at our Web site.

Graduates of the Toxicology major will be able to carefully design, execute and analyze experiments that extend the knowledge of toxicology and closely related sciences. They will be able to clearly communicate research findings, and thoroughly evaluate the literature of toxicology, contributing significantly to the advancement of the field.

Courses primarily for undergraduate students

Tox 419. Foodborne Hazards. (Cross-listed with FS HN, Micro). (3-0) Cr. 3. Alt. S., offered 2010.Prereq: Micro 201 or 302, a course in biochemistry. Pathogenesis of human microbiological foodborne infections and intoxications, principles of toxicology, major classes of toxicants in the food supply, governmental regulation of foodborne hazards. Only one of Tox 419 and 519 may count towards graduation. Nonmajor graduate credit.

Tox 420. Food Microbiology. (Cross-listed with FS HN, Micro). (3-0) Cr. 3. F.Prereq: Micro 201 or 302. Effects of microbial growth in foods. Methods to control, detect, and enumerate microorganisms in food and water. Foodborne infections and intoxications. Nonmajor graduate credit.

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Courses primarily for graduate students, open to qualified undergraduate students

Tox 501. Principles of Toxicology. (3-0) Cr. 3. F.Prereq: BBMB 404 or equivalent. Principles of toxicology governing entry, fate, and effects of toxicants on living systems. Includes toxicokinetics and foreign compound metabolism relative to toxification or detoxification. Fundamentals of foreign compound effects on metabolism, physiology, and morphology of different cell types, tissues, and organ systems.

Tox 502. Toxicology Methods. (0-6) Cr. 3. Alt. S., offered 2010.Prereq: Tox 501. Provides demonstrations or laboratory experience in the application of methods used in toxicology, including safety procedures, calculation and data analysis, teratologic and morphologic evaluation, electrophysiologic measures, in vitro enzyme induction/biotransformation, neural and behavioral toxicology testing.

Tox 504. Toxicology Seminar. (1-0) Cr. 1. Repeatable. F.S.SS.Prereq: Permission of instructor required. Presentation of a seminar about a current topic in toxicology as part of a weekly series of seminars by graduate students, faculty, and guest lecturers from off campus.

Tox 515. Regulatory Toxicology. (Cross-listed with FS HN). (1-0) Cr. 1. Alt. F., offered 2010.Prereq: BBMB 404 or FSHN 403. Regulatory toxicology in the real world. Approaches used by toxicologists in regulatory agencies for generating, enforcing and complying with laws and regulations in an unambiguous, defensible manner. Different obligations of scientists in research and regulatory settings. Perform simple risk assessments and suggest ways of dealing with data gaps. Examine strengths and weaknesses of common approaches used by regulatory agencies.

Tox 519. Food Toxicology. (Cross-listed with FS HN, NutrS). (3-0) Cr. 3. Alt. F., offered 2010.Prereq: A course in biochemistry. Basic principles of toxicology. Toxicants in the food supply: modes of action, toxicant defense systems, toxicant and nutrient interactions, risk assessment. Only one of TOX 419 and 519 may count toward graduation.

Tox 526. Veterinary Toxicology. (Cross-listed with VDPAM). (3-0) Cr. 3. S.Prereq: Permission of instructor. A study of disease processes in animals caused by toxicants and the use of differential diagnostic and therapeutic procedures. Emphasis is on use of clinical cases to define mechanism of poisoning, diagnostic and management procedures and public health and food safety issues.

Tox 546. Clinical and Diagnostic Toxicology. (Cross-listed with VDPAM). (0-3) Cr. 1-3. Repeatable. F.S.SS.Prereq: D.V.M. degree or 526. Advanced study of current problems and issues in toxicology. Emphasis on problem solving utilizing clinical, epidemiological, and laboratory resources.

Tox 550. Pesticides in the Environment. (Cross-listed with Ent). (2-0) Cr. 2. S.Prereq: 9 credits of biological sciences. Coats. Fate and significance of pesticides in soil, water, plants, animals, and the atmosphere.

Tox 554. General Pharmacology. (Cross-listed with B M S). (3-0) Cr. 3. S.Prereq: BMS 549 and 552; BBMB 404, 405. General principles; drug disposition; drugs acting on the nervous, cardiovascular, renal, gastrointestinal, and endocrine systems.

Tox 565. Methods of Biostatistics. (Cross-listed with Stat). (3-0) Cr. 3. Alt. F., offered 2009.Prereq: Stat 500 or 401; Stat 543 or 447. Statistical methods useful for biostatistical problems. Topics include analysis of cohort studies, case-control studies and randomized clinical trials, techniques in the analysis of survival data and longitudinal studies, approaches to handling missing data, and meta-analysis. Examples will come from recent studies in cancer, AIDS, heart disease, psychiatry and other human and animal health studies. Use of statistical software: SAS, S-Plus or R.

Tox 570. Risk Assessment for Food, Agriculture and Veterinary Medicine. (Cross-listed with Agron, VDPAM). (3-0) Cr. 3. Alt. F., offered 2009.Prereq: Stat 104 or consent of instructor: Wolt, Hurd. Risk assessment principles as applied to biological systems. Exposure and effects characterization in human and animal health and ecological risk assessment. Risk analysis frameworks and regulatory decision-making. Introduction to quantitative methods for risk assessment using epidemiological and distributional analyses. Uncertainty analysis.

Tox 575. Cell Biology. (Cross-listed with B M S). (3-0) Cr. 3. F.Prereq: 10 credits in biological science and permission of instructor. A multi-instructor course covering major topics in cell structure and function, including: universal features of prokaryotic and eukaryotic cells, types of utilization and conversion of energy, genetic control of cell shape and functionality, internal organization of cells, communication between cells and their environment, development of multicellular systems. Students have to write a term paper.

Tox 590. Special Topics. Cr. arr. Repeatable.Contact individual faculty for special projects or topics. Graded.

Courses for graduate students

Tox 626. Advanced Food Microbiology. (Cross-listed with FS HN, Micro). (3-0) Cr. 3. Alt. S., offered 2011.Prereq: FS HN 420 or 421 or 504. Topics of current interest in food microbiology, including new foodborne pathogens, rapid identification methods, effect of food properties and new preservation techniques on microbial growth, and mode of action of antimicrobials.

Tox 627. Rapid Methods in Food Microbiology. (Cross-listed with FS HN, Micro). (2-0) Cr. 2. Alt. S., offered 2010.Prereq: FS HN 420 or 421 or 504. Provides an overview of rapid microbial detection methods for use in foods. Topics include historical aspects of rapid microbial detection, basic categories of rapid tests (phenotypic, genotypic, whole cell, etc.), existing commercial test formats and kits, automation in testing, sample preparation and "next generation" testing formats now in development.

Tox 656. Cellular and Molecular Pathology II. (Cross-listed with V Pth). (3-0) Cr. 3. Alt. S., offered 2010.Prereq: Graduate course in biochemistry, genetics, or cell biology. Cellular and molecular mechanisms of carcinogenesis.

Tox 675. Insecticide Toxicology. (Cross-listed with Ent). (2-3) Cr. 3. Alt. F., offered 2009.Prereq: 501 or Ent 555. Coats. Principles of insecticide toxicology; classification, mode of action, metabolism, and environmental effects of insecticides.

Tox 697. Graduate Research Rotation. (0-12) Cr. 0-12. Repeatable. F.S.SS.Prereq: Admission to Toxicology graduate program. Graduate research projects performed under the supervision of selected faculty members in the graduate Toxicology major.

Tox 699. Research. Cr. arr. Repeatable.