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2007-2009 Courses and Programs

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Toxicology (Tox)

400 |Graduate Courses | www.toxicology. iastate.edu toxmajor@iastate.edu

(Interdepartmental Graduate Major)

Supervisory Committee: A. Kanthasamy, Chair; J. Coats, A. Kanthasamy, G. Kraus, P. Murphy, G. Osweiler

Work is offered for the degrees master of science and doctor of philosophy with a major in toxicology in various cooperating departments: Agricultural and Biosystems Engineering; Animal Science; Biochemistry, Biophysics and Molecular Biology; Biomedical Sciences; Chemistry; Entomology; Food Science and Human Nutrition; Genetics, Development and Cell Biology; Geological and Atmospheric Sciences; Natural Resource Ecology and Management; Physics; Plant Pathology; Veterinary Diagnostic and Production Animal Medicine; Veterinary Microbiology and Preventive Medicine; and Veterinary Pathology.

The prerequisites for entrance into the graduate toxicology major include an undergraduate degree in a relevant area of study; for example, chemical engineering, biology, biochemistry, chemistry, ecology, entomology, food science and technology, microbiology, nutritional science, zoology, or veterinary medicine. Minimum undergraduate coursework should include the following or their equivalent: 1 year of college mathematics, including calculus; 1 year of inorganic chemistry with quantitative analysis; 1 course in physics; 1 year of organic chemistry; 2 years of biological sciences including 1 course in physiology.

Other courses that are considered desirable in undergraduate preparation include: biochemistry, physical chemistry, qualitative analysis, and some specialized courses such as histology or advanced physiology. Prospective students not meeting these requirements may be admitted on a provisional basis with approval of the admissions committee and the program of study committee.

Facilities and faculty are available in these departments for fundamental research in such areas as environmental fate and effects of chemicals, food safety, neurotoxicology, nutritional toxicology, pesticides, and veterinary toxicology.

Students majoring in toxicology will be affiliated with a cooperating department. All Ph.D. students take a core curriculum consisting of Tox 501 and 502, 2 credits of Tox 504 (Toxicology Seminar), 7 additional credits in toxicology, 8 credits in biochemistry (from BBMB 404, 405, 420, 451, 511, 542), 3 graduate credits in physiology, histology, or pathology; Stat 401 and 402. M.S. students take a core of Toxicology 501 and 502, 1 credit of Toxicology 504 Seminar, 3 additional credits in toxicology, BBMB 404 and 405, Stat 401. Additional coursework is selected to meet departmental requirements and to satisfy individual student research interests; toxicology courses may be chosen from those listed below.

Graduates of the Toxicology major will be able to carefully design, execute and analyze experiments that extend the knowledge of toxicology and closely related sciences. They will be able to clearly communicate research findings, and thoroughly evaluate the literature of toxicology, contributing significantly to the advancement of the field.

A graduate minor in toxicology is available for students enrolled in other majors. A minor for an M.S. degree includes Tox 504 and 501 and 3 credits in other toxicology courses. A minor at the Ph.D. level includes Tox 504, 501, and 6 credits in other toxicology course work. One member of the student's program of study committee will be a member of the toxicology faculty.

Courses open for nonmajor graduate credit: 419, 420.

Courses primarily for undergraduate students

Tox 419. Foodborne Hazards. (Cross-listed with FS HN, Micro). (3-0) Cr. 3. Alt. S., offered 2008. Prereq: Micro 201 or 302, a course in biochemistry. Pathogenesis of human microbiological foodborne infections and intoxications, principles of toxicology, major classes of toxicants in the food supply, governmental regulation of foodborne hazards. Only one of Tox 419 and 519 may count towards graduation. Nonmajor graduate credit.

Tox 420. Food Microbiology. (Cross-listed with FS HN, Micro). (3-0) Cr. 3. F. Prereq: Micro 302. Effects of microbial growth in foods. Methods to control, detect, and enumerate microorganisms in food and water. Foodborne infections and intoxications. Nonmajor graduate credit.

Courses primarily for graduate students, open to qualified undergraduate students

Tox 501. Principles of Toxicology. (Cross-listed with VDPAM). (3-0) Cr. 3. F. Prereq: BBMB 404 or equivalent. Principles of toxicology governing entry, fate, and effects of toxicants on living systems. Includes toxicokinetics and foreign compound metabolism relative to toxification or detoxification. Fundamentals of foreign compound effects on metabolism, physiology, and morphology of different cell types, tissues, and organ systems.

Tox 502. Toxicology Methods. (Cross-listed with VDPAM). (0-6) Cr. 3. Alt. S., offered 2008. Prereq: Tox 501. Provides demonstrations or laboratory experience in the application of methods used in toxicology, including safety procedures, calculation and data analysis, teratologic and morphologic evaluation, electrophysiologic measures, in vitro enzyme induction/biotransformation, neural and behavioral toxicology testing.

Tox 504. Toxicology Seminar. (1-0) Cr. 1. Repeatable. F.S.SS. Prereq: Permission of instructor. Presentation of a seminar about a current topic in toxicology as part of a weekly series of seminars by graduate students, faculty, and guest lecturers from off campus.

Tox 515. Regulatory Toxicology. (1-0) Cr. 1. Alt. F., offered 2008. Prereq: BBMB 404 or FSHN 403. Regulatory toxicology in the real world. Approaches used by toxicologists in regulatory agencies for generating, enforcing and complying with laws and regulations in an unambiguous, defensible manner. Different obligations of scientists in research and regulatory settings. Perform simple risk assessments and suggest ways of dealing with data gaps. Examine strengths and weaknesses of common approaches used by regulatory agencies.

Tox 519. Food Toxicology. (Cross-listed with FS HN, NutrS). (3-0) Cr. 3. Alt. F., offered 2008. Prereq: A course in biochemistry. Basic principles of toxicology. Toxicants in the food supply: modes of action, toxicant defense systems, toxicant/nutrient interactions, risk assessment. Only one of TOX 419 and 519 may count toward graduation.

Tox 526. Veterinary Toxicology. (Cross-listed with VDPAM). (3-0) Cr. 3. S. Prereq: Permission of instructor. A study of disease processes in animals caused by toxicants and the use of differential diagnostic and therapeutic procedures.

Tox 546. Clinical and Diagnostic Toxicology. (Cross-listed with VDPAM). (0-3) Cr. 1-3. Repeatable. F.S.SS. Prereq: D.V.M. degree or 526. Advanced study of current problems and issues in toxicology. Emphasis on problem solving utilizing clinical, epidemiological, and laboratory resources.

Tox 550. Pesticides in the Environment. (Cross-listed with Ent). (2-0) Cr. 2. S. Prereq: 9 credits of biological sciences. Coats. Fate and significance of pesticides in soil, water, plants, animals, and the atmosphere.

Tox 554. General Pharmacology. (Cross-listed with B M S). (3-0) Cr. 3. S. Prereq: BMS 549 and 552; BBMB 404, 405. General principles; drug disposition; drugs acting on the nervous, cardiovascular, renal, gastrointestinal, and endocrine systems.

Tox 565. Methods of Biostatistics. (Cross-listed with Stat). (3-0) Cr. 3. Alt. F., offered 2007. Prereq: Stat 500 or 401; Stat 543 or 447. Statistical methods useful for biostatistical problems. Topics include analysis of cohort studies, case-control studies and randomized clinical trials, techniques in the analysis of survival data and longitudinal studies, approaches to handling missing data, and meta-analysis. Examples will come from recent studies in cancer, AIDS, heart disease, psychiatry and other human and animal health studies. Use of statistical software: SAS, S-Plus or R.

Tox 570. Risk Assessment for Food, Agriculture and Veterinary Medicine. (Cross-listed with Agron, VDPAM). (3-0) Cr. 3. Alt. F., offered 2008. Prereq: Stat 104 or consent of instructor: Wolt, Hurd. Risk assessment principles as applied to biological systems. Exposure and effects characterization in human and animal health and ecological risk assessment. Risk analysis frameworks and regulatory decision-making. Introduction to quantitative methods for risk assessment using epidemiological and distributional analyses. Uncertainty analysis.

Tox 575. Cell Biology. (Cross-listed with B M S). (3-0) Cr. 3. F. Prereq: 10 credits in biological science and permission of instructor. A multi-instructor course covering major topics in cell structure and function, including: universal features of prokaryotic and eukaryotic cells, types of utilization and conversion of energy, genetic control of cell shape and functionality, internal organization of cells, communication between cells and their environment, development of multicellular systems. Students have to write a term paper.

Tox 590. Special Topics. Cr. arr. Repeatable. Contact individual faculty for special projects or topics. Graded.

Courses for graduate students

Tox 626. Advanced Food Microbiology. (Cross-listed with FS HN, Micro). (3-0) Cr. 3. Alt. S., offered 2008. Prereq: FSHN 420 or 421 or 504. Topics of current interest in food microbiology, including new foodborne pathogens, rapid identification methods, effect of food properties and new preservation techniques on microbial growth, and mode of action of antimicrobials.

Tox 656. Cellular and Molecular Pathology II. (Cross-listed with V Pth). (3-0) Cr. 3. Alt. S., offered 2008. Prereq: Graduate course in biochemistry, genetics, or cell biology. Cellular and molecular mechanisms of carcinogenesis.

Tox 675. Insecticide Toxicology. (Cross-listed with Ent). (2-3) Cr. 3. Alt. F., offered 2007. Prereq: Ent 555 or Tox 501. Coats. Principles of insecticide toxicology; classification, mode of action, metabolism, and environmental effects of insecticides.

Tox 699. Research. Cr. arr. Repeatable.