POSTDOCTORAL POSITION
(Updated January 6, 2006 )

Comparative and functional genomics of host and tissue specificity among plant pathogenic xanthomonads

We recently have obtained draft genome sequences of Xanthomonas oryzae pv. oryzicola (Xoc) strain BLS256 and X. campestris pv. armoraciae (Xca) strain 756C. Closure of both genomes is in progress. Together with the published genomes of X. oryzae pv. oryzae (Xoo; two strains) and X. campestris pv. campestris (Xcc; two strains), these provide paired sets of genomes of vascular and non-vascular pathogens of rice (Xoo and Xoc) and Arabidopsis (Xcc and Xca), enabling a comprehensive comparative genomics approach to understanding host-and tissue-specificity in bacterial pathogenesis of plants using the leading models for monocot and dicot biology. A creative and diligent individual with a strong record of productivity, excellent communication skills, and keen motivation to address important problems in plant pathology through fundamental research is sought to:

  • Identify differences in gene content that correlate with host and tissue specificity using a combination of computational tools and molecular biology to compare sequenced isolates and a diverse set of isolates not yet sequenced.
  • Functionally characterize candidate determinants of specificity by mutagenesis and heterologous expression, as well as in planta expression, biochemistry, and other approaches, as appropriate.

The individual also will have the opportunity to contribute to other, ongoing projects, including but not limited to:

  • Isolating and characterizing the component(s) required for differential hrp gene expression observed between Xoo and Xoc
  • Elucidating the mechanism of inhibition of R gene mediated defense in rice by Xoc that we have recently described (Makino et al, MPMI in press)
  • Characterizing plant determinants of tissue specificity by mutant analysis and profiling of plant responses to vascular vs non-vascular pathogens.

To apply, send one pdf file containing:

  • A statement of research interests and experience, and long term goals
  • A curriculum vitae, including a list of publications
  • Contact information for three references
to ajbog@iastate.edu, or send a hard copy of these documents to Adam Bogdanove, Department of Plant Pathology, Iowa State University, Ames, IA 50011 USA. Applications will be accepted until the position is filled. To guarantee consideration, applications must be received by February 1, 2006.













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