• Available on the library website -- Collections ---> e-resources by Subject
• Lists relevant books (online & print) and article databases. Also includes links to recent ISU publications related to genetics.
• Off-campus access to library resources - click on the "Off-campus login" tab for more information.
  

II. PubMed (Select PubMed – ISU Affiliate from the "Indexes & Abstracts" link. This link has the "Get it@ISU" feature enabled. You may also access PubMed via the "Find Articles" tab on the GDCB Resources guide)

• PubMed: service of the NIH and NLM. Freely available search interface for the MEDLINE database.
• Combine search terms with connector words: "AND", "OR" or "NOT". Must use upper-case letters. When searching for gene-related information, can use gene symbol/abbreviation, protein name, etc.
• Utilize "Limits" (e.g. Publication type, Language, Publication Date, etc.)
• "Send to Email" function
• Other features: Books (Genes & Disease, GeneReviews)
• Additional information:
  • PubMed Tutorials http://www.nlm.nih.gov/bsd/disted/pubmed.html

III. OMIM: Online Mendelian Inheritance in Man

• OMIM: Online Mendelian Inheritance in Man (linked from PubMed, look at the black toolbar). Catalog of review articles for human genes and genetic disorders maintained by Johns Hopkins University.
  • MIM Number Prefixes: * - gene with a known sequence; # - before an entry number indicates that it is a descriptive entry, usually of a phenotype, and does not represent a unique locus; + - before an entry number indicates that the entry contains the description of a gene of known sequence and a phenotype; % - before an entry number indicates that the entry describes a confirmed mendelian phenotype or phenotypic locus for which the underlying molecular basis is not known. Example: presenilin 1 AND alzheimer disease
    

IV. Entrez Gene (From NCBI homepage, click on "Genomic Biology" on the left-hand sidebar, then choose "Gene")

• NCBIs database for gene-specific information. Many species represented----not just human information.
• Can search by name of disease, gene name. Can limit search by species. For example, cx26 [sym] AND human [orgn]
• Can easily find information about chromosome, map location, number of amino acids in a gene's peptide, function & location of the gene's peptide.
• Extensive linkages to other NCBI databases (e.g. Entrez Nucleotide, Entrez Protein, OMIM, PubMed)
• Many links to resources outside of the NCBI (e.g. HPRD: Human Protein Reference Database, KEGG: Kyoto Encyclopedia of Genes and Genomes)
• Tips for answering Question #3 on the datasheet (PDF): http://www.public.iastate.edu/~adinkelm/Using_Entrez_GENE.pdf

V. Resources with easy-to-understand information about genetics and human disease

• MedlinePlus Health Information (http://www.medlineplus.gov/)
  • Genes & Gene Therapy, http://www.nlm.nih.gov/medlineplus/genesandgenetherapy.html
• Genetics Home Reference (http://ghr.nlm.nih.gov/)
  • Search by genetic condition, specific gene, or chromosome.
  • See article, "What is Gene Therapy?", http://ghr.nlm.nih.gov/handbook/therapy/genetherapy

VI. Online Glossaries/Dictionaries

• Talking Glossary of Genetic Terms (http://www.genome.gov/glossary.cfm)
• Medical Dictionary (http://www.nlm.nih.gov/medlineplus/mplusdictionary.html)
• GeneTests Glossary - definitions include illustrations. This is excellent.

VII. For More Information - E-Books - Both of the following books have articles about gene therapy. Both e-books are available through the Library website, http://www.lib.iastate.edu/ (Do a "Title" search in the catalog or click on the "Find Books" tab in the GDCB Resources guide.)

• Encyclopedia of Genetics, Genomics, Proteomics & Bioinformatics.
• Encyclopedia of Life Sciences

VIII. Google Scholar

• Looking for the most current information about genetic disease (or any scientific topic)? Use PubMed, not Google Scholar! You will find "scholarly" references in Google Scholar, but the information may not be the most up-to-date. MEDLINE is generally updated each day, Tuesday-Saturday.

Last updated 03/23/2009 - Available at: http://www.public.iastate.edu/~adinkelm/homepage.html