Recent Publications

Shen, C., Shao, Z., and J.A. Powell-Coffman, (2006).  The Caenorhabditis elegans rhy-1 gene inhibits HIF-1 hypoxia-inducible factor activity in a negative feedback loop that does not include vhl-1.  Genetics Vol 174 (3):1205-14

Qin, H., Zhai, Z., and Powell-Coffman, J.A. (2006)  The Caenorhabditis elegans AHR-1 transcription complex controls expression of soluble guanylate cyclase genes in the URX neurons and regulates aggregation behavior.  Developmental Biology,298: 20580

Shen, C. and Powell-Coffman, J.A.  (2005)  Genome-wide analysis of hypoxia response in C. elegans and identification of genes regulated by HIF-1. Journal of Biological Chemistry, 280(21):20580-8

Qin, H. and J. A. Powell-Coffman (2004) Regulation of neuronal development by AHR-1, the C. elegans aryl hydrocarbon receptor.  Developmental Biology, 270: 64-75.

Huang, X., Powell-Coffman, J. A., and Y. Jin (2004) The AHR-1 aryl hydrocarbon receptor and its co-factor the AHA-1 aryl hydrocarbon receptor nuclear translocator specify GABAergic neuron cell fate in C. elegans.  Development 131: 819-28.

Shen, C. and Powell-Coffman, J. A. (2003) Genetic analysis of hypoxia signaling and response in C. elegans.  Ann. New York Acad. Sci. 995: 191 - 199.

Treinin, M., Schleyer, J., Jiang, H., Powell-Coffman, J. A., Bromberg, Z., and M. Horowitz (2003)  HIF-1 is required for heat acclimation in the nematode C. elegans.  Physiological Genomics Vol 14, 17-24 

Powell-Coffman, J.A.  (2003) bHLH-PAS proteins in C. elegans.  In PAS Proteins:  Regulators and Sensors of Development and Physiology (Editor S. Crews). Kluwer Academic Publishers.  Norwell, MA. pp 51 - 68

Jiang, H., Guo, R., and J. A. Powell-Coffman (2001) The Caenorhabditis elegans hif-1 gene encodes a bHLH-PAS protein that is required for adaptation to hypoxia. Proc. Natl. Acad. Sci. U. S. A. 98: 7916 – 7921

Powell-Coffman, J.A., Bradfield, C.A., and W.B. Wood. (1998) C. elegans orthologs of the aryl hydrocarbon receptor and its heterodimerization partner the aryl hyrdrocarbon receptor nuclear translocator.   Proc. Natl. Acad. Sci. U. S. A. 95: 2844-2849

Powell-Coffman, J.A., Knight, J., and W.B. Wood. (1996) Onset of C. elegans gastrulation is blocked by inhibition of embryonic transcription with an RNA polymerase antisense RNA. Dev. Biol. 178: 472-483.