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ADAM J. BOGDANOVE

November 14, 2008

Professional Preparation

Boyce Thompson Institute	Molecular Plant Pathology	Postdoc., 1998-2000
Purdue University	Agronomy	Postdoc., 1997-1998
Cornell University	Plant Pathology	Ph.D., 1997
Yale University	Biology, cum laude	B.S., 1987

Positions held

2006-present Iowa State University	Associate Professor, Dept. of Plant Pathology, also Bioinformatics and Computational Biology, Interdepartmental Genetics, Interdepartmental Microbiology, Interdepartmental Plant Physiology Major, Molecular Cell and Developmental Biology, and Plant Sciences Institute Center for Plant Responses to Environmental Stress Chair, Interdepartmental Microbiology Graduate Program Member, Biotechnology Council
2000-2006 Iowa State University	Assistant Professor, Dept. of Plant Pathology, also Interdepartmental Genetics, Bioinformatics and Computational Biology, Molecular Cell and Developmental Biology, Interdepartmental Microbiology, and Plant Sciences Institute Center for Plant Responses to Environmental Stress
1997-1999	USDA-NRI Postdoctoral Research Fellow
1991-1994	USDA National Needs Graduate Research Fellow
1987-1991	Instructor of English as a Second Language, Japan

Research Focus

Molecular mechanisms of bacterial plant pathogenesis and plant defense: bacterial type III secretion, plant signal transduction, microbial and plant biotechnology for disease control.

Publications

Research articles

Lu, H., Patil, P., Van Sluys, M.-A., White, F.F., Ryan, R.P., Dow, J.M., Rabinowicz, P., Salzberg, S.L., Leach, J.E., Sonti, R., Brendel, V., and Bogdanove, A.J. (2008). Acquisition and evolution of plant pathogenesis-associated gene clusters and candidate determinants of tissue-specificity in Xanthomonas. PLoS ONE 3:e3828 (available Nov 27, 2008).

Seo, Y.-S., Sriariyanun, M., Wang, L., Pfeiff, J., Phetsom, J., Lin, Y., Jung, K.-H., Chou, H.-H., Bogdanove, A.J., and Ronald, P.C. (2008). A two-genome microarray for the rice pathogens Xanthomonas oryzae pv. oryzae and X. oryzae pv. oryzicola and its use in the discovery of a difference in their regulation of hrp genes. BMC Microbiology 8:99.

Salzberg, S.L., Sommer, D.D., Schatz, M.C., Phillippy, A.M., Rabinowicz, P.D., Tsuge, S., Furutani, A., Ochiai, H., Delcher, A.L., Kelley, D., Madupu, R., Puiu, D., Radune, D., Shumway, M., Trapnell, C., Aparna, G., Jha, G., Pandey, A., Patil, P.B., Ishihara, H., Meyer, D.F., Szurek, B., Verdier, V., Koebnik, R., Dow, J.M., Ryan, R.P., Hirata, H., Tsuyumu, S., Lee, S.W., Ronald, P.C., Sonti, R.V., Van Sluys, M.-A., Leach, J.E., White, F.F., and Bogdanove, A.J. (2008). Genome sequence and rapid evolution of the rice pathogen Xanthomonas oryzae pv. oryzae PXO99^A. BMC Genomics 9:204.

Patil, P.B., Bogdanove, A.J., and Sonti, R.V. (2007). The role of horizontal transfer in the evolution of a highly variable lipopolysaccharide biosynthesis locus in xanthomonads that infect rice, citrus and crucifers. BMC Evol. Biol. 7:243.

Wang, L. Makino, S., Subedee, A. and Bogdanove, A.J. (2007) Novel candidate virulence factors in rice pathogen Xanthomonas oryzae pv. oryzicola revealed by mutational analysis. Applied Env. Microbiol. 73:8023-8027.

Nissinen, R.M, Ytterberg, A.J., Bogdanove, A.J., van Wijk, K.J., and Beer, S.V. (2007) Analyses of the secretomes of Erwinia amylovora and selected hrp mutants reveal novel type III secreted proteins and an effect of HrpJ on extracellular harpin levels. Molecular Plant Pathol. 8:55-67.

Wang, L., Eggenberger, A.L., Hill, J., and Bogdanove, A.J. (2006). Pseudomonas syringae effector avrB confers soybean cultivar-specific avirulence on Soybean mosaic virus adapted for transgene expression but effector avrPto does not. Mol. Plant-Microbe Interact.19:304-312.

Makino, S., Sugio, A., White, F.F., and Bogdanove, A.J. (2006). Inhibition of resistance gene mediated defense in rice by Xanthomonas oryzae pv. oryzicola. Mol. Plant-Microbe Interact.19:240-249.

Nino-Liu, D.O., Darnielle, L., and Bogdanove, A.J. (2005). A simple method of mass inoculation of rice effective for both pathovars of Xanthomonas oryzae, and the construction of comparable sets of host cDNA libraries spanning early stages of bacterial leaf blight and bacterial leaf streak. J. Phytopathol. 153, 500-504.

Bogdanove, A.J. and Martin, G.B. (2000). AvrPto-dependent Pto-interacting proteins and AvrPto-interacting proteins in tomato. Proc. Natl. Acad. Sci. 97: 8836-8840.

Bogdanove, A.J., Bauer, D.W., and Beer, S.V. (1998). Erwinia amylovora secretes DspE, a pathogenicity factor and functional AvrE homolog, through the Hrp (type III secretion). pathway. J. Bacteriol. 180:2244-2247.

Bogdanove, A.J., Kim, J.F., Wei Z.-M., Kolchinsky, P., Charkowski, A.O., Conlin, A.K., Collmer, A., and Beer, S.V. (1998). Homology and functional similarity of an hrp-linked pathogenicity locus, dspEF, of Erwinia amylovora and the avirulence locus avrE of Pseudomonas syringae pathovar tomato. Proc. Natl. Acad. Sci. 95: 1325-1330.

Bogdanove, A.J., Beer, S.V., Bonas, U., Boucher, C.A., Collmer, A., Coplin, D.L., Cornelis, G.R., Huang, H.-C., Hutcheson, S.W., Panopoulos, N.J., and Van Gijsegem, F. (1996). Unified nomenclature for broadly conserved hrp genes of phytopathogenic bacteria. Mol. Microbiol. 20:681-683.

Bogdanove, A.J., Wei, Z.-M., Zhao, L., and Beer, S.V. (1996). Erwinia amylovora secretes harpin via a Type III pathway and contains a homolog of yopN of Yersinia spp. J. Bacteriol. 178:1720-1730.

Bauer, D.W., Bogdanove, A.J., Beer, S.V., and Collmer. A. (1994). Erwinia chrysanthemi hrp genes and their involvement in soft rot pathogenesis and elicitation of the hypersensitive response. Mol. Plant-Microbe Interact. 7:573-581.

Review articles, book chapters, and conference proceedings

Meyer, D.F., and Bogdanove, A.J. (2008). Genomics-driven advances in Xanthomonas biology. In Plant Pathogenic Bacteria: Genomics and Molecular Biology, R.W. Jackson, ed. (Norwich, UK, Horizon Scientific Press), pp. 147-161.

Wise, R.P., Moscou, M.J., Bogdanove, A.J., and Whitham, S.A. (2007). Transcript profiling in host-pathogen interactions. Ann. Rev. Phytopathol. 45:329-369.

Nino-Liu, D. O., Ronald, P. C., and Bogdanove, A. J. (2006) Xanthomonas oryzae pathovars: model pathogens of a model crop. Molecular Plant Pathol. 7:303-324.

Wang, L., Mahama, A., Darnielle, L., Eggenberger, A., Hill, J., and Bogdanove, A.J. (2005). Recognition of the bacterial effector protein AvrPto in soybean – a case of HR-independent resistance, pp. 103-114 in Genomic and Genetic Analysis of Plant Parasitism and Defense, Proceedings of the 9^th Japan-US Seminar on Plant-Pathogen Interactions, Shizuoka, Japan, November 1-7, 2003, APS Press, St. Paul.

Martin, G.B., Bogdanove, A.J., Sessa, G. (2003). Understanding the functions of plant disease resistance proteins. Annu. Rev. Plant Biol. 54: 23-61.

Bogdanove, A.J. (2002). Pto update: recent progress on an ancient plant defense signaling pathway. Molecular Plant Pathol. 3: 283-288.

Bogdanove, A.J. (2002). Protein-protein interactions in pathogen recognition by plants. Plant Mol. Biol. 50:981-989.

Devarenne, T.P., Riely, B.K., Lin, N.-C., Kim, Y.-J., Cohn, J., Mysore, K., Charkravarthy, S., Bogdanove, A.J., DπAscenzo, M., Debbie, P., Tuori, B., Martin, G.B. (2002). Recognition of Pseudomonas effector proteins by tomato and profiling of plant gene expression changes that occur during plant-pathogen interactions, pp. 58-63 in Biology of Plant-Microbe Interactions, Vol. 3: Proceedings of the 10^th International Symposium on Molecular Plant-Microbe Interactions, Madison, Wisconsin, USA, July 10-14, 2001. IS-MPMI, St. Paul, MN.

Bogdanove, A.J., Gu, Y.-Q., Nakajima, Y. , Sessa, G. , and Martin, G.B. (1999). Early events in AvrPto/Pto-mediated activation of defense responses, pp. 238-242 in Biology of Plant-Microbe Interactions: Proceedings of the 9^th International Symposium on Molecular Plant-Microbe Interactions, Amsterdam, The Netherlands, July 25-30, 1999. IS-MPMI, St. Paul, MN.

Bogdanove, A.J., Kim, J.F., and Beer, S.V. (1999). Disease-specific genes of Erwinia amylovora: keys to understanding pathogenesis and potential targets for disease control pp. 163-177 in Fire Blight and Its Causative Agent, Erwinia amylovora. J. L. Vanneste (ed.). CAB International, Wallingford, UK.

Websites and web-based resources

Westgate, M., Vogel, K., Darnielle, L., and Bogdanove, A.J. (under development). Xanthomonas Genomics Resource at http://www.plantpath.iastate.edu/xgr.

Darnielle, L., Vogel, K., and Bogdanove, A.J. (2002 onward). Functional genomics of rice susceptibility to bacterial pathogens at www.public.iastate.edu/~ajbog/nsf.

Vogel, K., Darnielle, L., and Bogdanove, A.J. (2001 onward). Bogdanove laboratory at www.public.iastate.edu/~ajbog.

Invited seminars

Extramural

Dept. of Plant Pathology, UC Davis, November 2008

Martin Luther University Halle-Wittenberg, Institute for Genetics, May 2008.

Prokagenome 2007: 3^rd European Conference on Prokaryotic Genomics, Goettingen, Germany, October 2007.

2^nd International Conference on Bacterial Blight of Rice, Nanjing, China, September 2007.

University of Wisconsin, Madison, Department of Plant Pathology, September 2007.

USDA-NSF Microbial Genome Sequencing Program Workshop, Plant and Animal Genome Conference, San Diego, CA, January 2007.

2^nd International Workshop on Xanthomonas: Genomics, Bielefeld, Germany, October 2005.

American Microbiology Society, 65^th annual meeting of the North Central Branch, Ames, IA, September 2005.

University of Minnesota, Department of Plant Pathology seminar mini-series on plant resistance genes, October 2004.

1^st International Conference on Bacterial Blight of Rice, Tsukuba, Japan, March 2004.

9^th Japan-US seminar on Plant-Pathogen Interactions, Genomic and Genetic Analysis of Plant Parasitism and Defense, Shizuoka, Japan, November 2003.

Iowa Soybean Promotion Board Meeting, Ames, IA, February 2002.

52^nd Harden Conference, Signalling in Plants, Wye, Kent UK, September, 2000.

Invitation declined: International Plant Protection Congress, Beijing, PRC, May 2004.

Intramural

Interdepartmental Graduate Program in Genetics, September, 2008

Interdepartmental Graduate Program in Plant Biology, September, 2008

Genetics Cell and Developmental Biology, September 2007.

Interdepartmental Graduate Programs recruiting weekend, February 2005.

Plant Sciences Institute visit of World Food Prize laureate Longing Yuan, October 2004.

Center for Plant Responses to Environmental Stress seminar series, October 2004.

Bioinformatics and Computational Biology faculty seminar series, October 2004.

Department of Plant Pathology, April 2003.

Bioinformatics and Computational Biology faculty seminar series, November 2002.

Molecular Cell and Developmental Biology Program, May 2001.

Department of Microbiology, March, 2001.

Interdepartmental Genetics, November, 2000.

Grants and Other Awards and Achievements

NSF Plant Genome Research Program (2008-2012). GEPR: Transcription profiling and functional analyses of bacterial disease susceptibility pathways of rice. Co-PI.

USDA-CSREES NRI, 51.8 Microbial Associations with Plants (2008-2011). Role of lipopolysaccharide O-chain in type III secretion, and effector-mediated host defense inhibition in bacterial leaf streak of rice. PI.

NSF Young Investigator Award in Plant Genome Research, supplement (2005). Functional genomics of rice susceptibility to bacterial diseases: use of the 45K rice oligo microarray. PI

USDA-NSF Microbial Genome Sequencing Program (2004-2006). Xanthomonas pathovars enabling a broad comparative genomics approach to understanding vascular and non-vascular bacterial diseases of dicots and monocots. PI (co-PIs at Colorado State Univ., Kansas State Univ., and The Institute for Genome Research).

NSF Young Investigator Award in Plant Genome Research (2002-2008). Functional genomics of rice susceptibility to bacterial diseases. PI.

Iowa State University Special Research Initiative Grant (2000). Sequencing the Xanthomonas oryzae genome at Iowa State: a feasibility study. PI.

Iowa State University Plant Sciences Institute Grants Program (2001-2003). Interaction specificity of related bacterial avirulence proteins and their cognate receptors in soybean and tomato. PI.

USDA-NRIGCP Postdoctoral Fellowship (1997-1999). Role of AvrPto-Pto binding in Activation of Pto-mediated Disease Resistance. PI.

NSF/Japan Ministry of Education Young Researchers' Summer Program (1996).

USDA National Needs Graduate Fellowship (1991-1994).

Patents

Bauer, D.W., Beer, S.V., Bogdanove, A.J., Collmer, A., and Ham, J.H. (2003). Recombinant constructs and systems for secretion of proteins via type III secretion systems. Patent No. US 6596509.

Bogdanove, A.J., Kim, J.F., Wei, Z.-M., and Beer, S.V. (2001). Hypersensitive response elicitor from Erwinia amylovora, its use, and encoding gene. Patent No. US 6228644.

Teaching

Plant Pathology 692. Molecular Biology of Plant-Microbe Interactions. 3 cr.

Genetics 692. Seminar in the Conceptual Foundations of Genetics. 1 cr.

Presentations made at schools and other organizations or to visiting groups

Science Bound program of ISU (2008). As a faculty volunteer for this program to increase the involvement of disadvantaged and/or underrepresented students in science, I organized presentations by three graduate students from underrepresented groups regarding their reasons for choosing a scientific career, led a discussion on careers in science, and provided a hands-on activity in plant pathology and hypothesis testing for central Iowa eighth graders. Participation: 26 students, 5 teachers, administrators, and adult mentors.

Plants Get Sick Too (2001-2005). I developed and have conducted yearly this program for Science Night at Roosevelt Elementary School, Ames, IA. The program consists of demonstrations and activities for students and their families focusing on hypothesis testing and plant pathology. Participation: 80-100.

Science Bound program of ISU (2004). As a faculty volunteer for this program to increase the involvement of disadvantaged and/or underrepresented students in science, I organized presentations by two graduate students and a postdoctoral researcher of color regarding reasons for choosing a scientific career, led a general discussion on being a scientist, and provided a hands-on exercise in plant pathology for central Iowa high school freshmen. Participation: 24.

ISU College of Ag High School Student Workshop (Science in Ag Day), "Biosecurity Investigations” (2003). With another faculty member, I conducted an hour-long introduction to crop biosecurity for central Iowa high school seniors. Participation: 20.

Research internship programs

Scinece with Practive (AgEd 490) (2005-present). I mentor undergraduate participants in this program, which focuses on education and training through hourly employment. Students gain experience and training as research assistants in my lab

NSF Research Experience for Teachers, A. Leshem-Ackerman and J. Wendel, ISU, PIs (2003, 2005, 2006). I host interns in this summer program to provide research experience and resources for curriculum development for junior and senior high school teachers.

Romania Young Scientist to Scientist Program, ISU (2004). I hosted a young Romanian scientist for a one month research experience in my laboratory as part of this international outreach program funded by USAID and USDA and administered by the ISU Global Agricultural Programs Office.

NSF Research Experience for High School Students, A. Leshem-Ackerman and J. Wendel, ISU, PIs (2004). I hosted a high school student for a semester-long internship in my laboratory as part of this outreach program to expose students early to research in the life sciences.

NSF Research Experience for Undergraduates, D. Oliver, ISU, PI (2002, 2004). I hosted an undergraduate student each year for a summer research internship as part of this outreach program that recruits largely from 1890 institutions.

Program for Women in Science and Engineering, summer research internships (2002, 2003). I hosted one undergaduate woman each year for a summer research internship as part of this program to increase the participation of women in the sciences.

Membership and service in professional societies

International Society for Molecular Plant Microbe Interactions. Co-chair of ad hoc committee to update membership brochure (2001).

American Phytopathological Society. Bacteriology committee (2004-2005).

American Society for Microbiology.

American Society for Plant Biology.